A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity
文献类型：期刊论文
| 作者 | Li,Xiaomei; Li,Shanni; Liu,Jie ; Lin,Lisha; Sun,Huifang; Yang,Wenjiao; Cai,Ying; Gao,Na; Zhou,Lutan; Qin,Hongbo
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2021 |
| 卷号 | 256页码:117513 |
| 关键词 | fucan sulfate peroxide depolymerization oligosaccharides anti-thrombin activity FUCOSYLATED CHONDROITIN SULFATE FREE-RADICAL DEPOLYMERIZATION PHYSICOCHEMICAL CHARACTERISTICS REPEATING UNIT BODY-WALL SEA FUCOIDAN GLYCOSAMINOGLYCAN POLYSACCHARIDES HEPARIN |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2020.117513 |
| 英文摘要 | Marine sulfated polysaccharides have aroused widespread concern for their various structures and bioactivities. Peroxide depolymerization is a common strategy in analysis of structures and structure-activity relationships of polysaccharides. However, confirming the depolymerization process and exact structures of the degradation products is still a considerable challenge. This study reported the structures of a fucan sulfate (FS) from sea cucumber Stichopus herrmanni and its depolymerized products (dFS) prepared by peroxide degradation. The FS was elucidated with a highly regular structure, {-3)-L-Fuc(2S)-(alpha 1-}n. Structure analysis of oligosaccharides purified from dFS suggested that peroxide degradation involved in cleavage of glycosidic bonds and oxidative modification of reducing end of sugar residue, while no break in sugar ring was observed. Both FS and series of dFSs exhibited significant anticoagulant activities due to their anti-thrombin effects in presence of heparin cofactor II and their potencies were related to their molecular sizes, dFS with similar to 20 kDa showed the strongest activity. |
| WOS记录号 | WOS:000613255400002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73349]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chuxiong Med Coll, Chuxiong 675005, Peoples R China 2.Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.South Cent Univ National, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li,Xiaomei,Li,Shanni,Liu,Jie,et al. A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity[J]. CARBOHYDRATE POLYMERS,2021,256:117513. |
| APA | Li,Xiaomei.,Li,Shanni.,Liu,Jie.,Lin,Lisha.,Sun,Huifang.,...&Zhao,Jinhua.(2021).A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity.CARBOHYDRATE POLYMERS,256,117513. |
| MLA | Li,Xiaomei,et al."A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity".CARBOHYDRATE POLYMERS 256(2021):117513. |
入库方式： OAI收割
来源：昆明植物研究所
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