3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.
文献类型：期刊论文
| 作者 | Zhou,Yuan-Fei; Hu,Kun ; Wang,Fang; Tang,Jian-Wei; Zhang,Liang; Sun,Han-Dong; Cai,Xiang-Hai; Puno,Pema-Tenzin
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2021 |
| 卷号 | 84期号:4页码:1244-1253 |
| 关键词 | DOUBLE-BLIND CYCLODEPSIPEPTIDES CONFIGURATION METABOLITES SUROTOMYCIN VANCOMYCIN ADULTS FUNGI H-1 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.0c01305 |
| 英文摘要 | An investigation of an endolichenic Beauveria sp. led to the discovery of seven new cyclotetradepsipeptides, beauveamides A-G (2-8), along with the known beauverolide Ka (1). All incorporate a 3-hydroxy-4-methyldecanoic acid (HMDA) moiety in their structures. Their configuration was determined through Marfey's, J-based configuration analysis, and NMR computational methods, representing the first time that the stereostructures of HMDA-moiety-containing cyclotetradepsipeptides have been established. Compounds 1 and 2 exhibited protecting effects on HEI-OC1 cells at 10 mu M, while 1, 4, and 5 could stimulate glucose uptake in cultured rat L6 myoblasts at 50 mu M. Compound 1 showed dose-dependent activity in both L6 myoblasts and myotubes. |
| WOS记录号 | WOS:000644478400032 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73364]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Wang, Fang 2.Zhang, Liang 3.Tang, Jian-Wei 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 7.Cai, Xiang-Hai 8.Sun, Han-Dong 9.[Zhou, Yuan-Fei 10.Hu, Kun |
| 推荐引用方式 GB/T 7714 | Zhou,Yuan-Fei,Hu,Kun,Wang,Fang,et al. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1244-1253. |
| APA | Zhou,Yuan-Fei.,Hu,Kun.,Wang,Fang.,Tang,Jian-Wei.,Zhang,Liang.,...&Puno,Pema-Tenzin.(2021).3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp..JOURNAL OF NATURAL PRODUCTS,84(4),1244-1253. |
| MLA | Zhou,Yuan-Fei,et al."3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1244-1253. |
入库方式： OAI收割
来源：昆明植物研究所
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