Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents
文献类型：期刊论文
| 作者 | Su,Hai-Guo; Wang,Qian; Zhou,Lin; Peng,Xing-Rong; Xiong,Wen-Yong ; Qiu,Ming -Hua
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| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 112页码:104977 |
| ISSN号 | 0045-2068 |
| 关键词 | Ganoderma applanatum Lanostane triterpenoids Antiadipogenic effects LANOSTANE-TYPE TRITERPENOIDS ACID |
| DOI | 10.1016/j.bioorg.2021.104977 |
| 英文摘要 | Previously, we have demonstrated the antiadipogenic benefits of Ganoderma triterpenoids (GTs), which indicated GTs have potential therapeutic implications for obesity. In this study, the EtOAc extract of Ganoderma applanatum was further phytochemically investigated for searching new antiadipogenic agents, which led to the isolation of a total of 15 highly oxygenated lanostane triterpenoids, including 9 new compounds (1-9) and 6 known analogues (10-15). Structurally, ganodapplanoic acids A and B (1, 2) are two rearranged 6/6/5/6-fused lanostane-type triterpenoids with an unusual C-13/C-15 oxygen bridge moiety. In addition, the EtOAc extract (GAE) and isolates (1-4,6-15) were assayed for their antiadipogenic effects in 3T3-L1 adipocytes. The results revealed that compound 9 effectively repressed adipogenesis through down-regulating the expression of major proteins (PPAR gamma, CEBP beta and FAS) involving differentiation and adipogenesis in 3T3-L1 adipocytes. Thus, the present study further demonstrated the antiadipogenic potential of GTs and provided a possible perspective for obesity treatment. |
| WOS记录号 | WOS:000661870700007 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73379]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Wang, Qian 2.Yunnan Univ, Key Lab Med Chem Nat Resource, Kunming 650500, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.[Su, Hai-Guo 5.Zhou, Lin 6.Peng, Xing-Rong 7.Xiong, Wen-Yong 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su,Hai-Guo,Wang,Qian,Zhou,Lin,et al. Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents[J]. BIOORGANIC CHEMISTRY,2021,112:104977. |
| APA | Su,Hai-Guo,Wang,Qian,Zhou,Lin,Peng,Xing-Rong,Xiong,Wen-Yong,&Qiu,Ming -Hua.(2021).Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents.BIOORGANIC CHEMISTRY,112,104977. |
| MLA | Su,Hai-Guo,et al."Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents".BIOORGANIC CHEMISTRY 112(2021):104977. |
入库方式： OAI收割
来源：昆明植物研究所
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