Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis
文献类型：期刊论文
| 作者 | Zhang,Quanwei; Liu,Man; Li,Lifeng; Chen,Miaomiao; Puno,Pema Tenzin; Bao,Wanrong; Zheng,Hongming; Wen,Xin; Cheng,Huiyuan; Fung,Hauyee |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2021 |
| 卷号 | 271页码:118443 |
| 关键词 | Cordyceps Polysaccharide TLR4 MyD88 p38 Immune responses Macrophage NF-KAPPA-B STRUCTURAL-CHARACTERIZATION ANTIOXIDANT ACTIVITY MYCELIAL FERMENTATION SIGNALING PATHWAYS FRUITING BODIES SINENSIS FUNGUS GENE-EXPRESSION LIPOPOLYSACCHARIDE RECOGNITION |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2021.118443 |
| 英文摘要 | Cordyceps, one of the most expensive natural health supplements, is popularly used to modulate immune function. However, little is known regarding the underlying mechanism of its immunomodulatory activity. We newly reported a Cordyceps quality marker CCP (Mw 433.778 kDa) which was characterized as a 1,4-alpha glucan by chemical and spectral analysis and is able to induce significant immune responses of macrophages. Herein, we further investigated the molecular mechanism of CCP's immunomodulatory effects. The results indicate that CCP modulates the TLR4/MyD88/p38 signaling pathway of macrophages, where TLR4 plays a crucial role as verified on TLR4-deficient (TLR4-/-) bone marrow-derived macrophages (BMDMs) and TLR4-/- mice. These findings provide a precise understanding of the molecular mechanism of Cordyceps' immunomodulatory benefits. |
| WOS记录号 | WOS:000685061700006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73416]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang,Quanwei,Liu,Man,Li,Lifeng,et al. Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis[J]. CARBOHYDRATE POLYMERS,2021,271:118443. |
| APA | Zhang,Quanwei.,Liu,Man.,Li,Lifeng.,Chen,Miaomiao.,Puno,Pema Tenzin.,...&Sun,Handong.(2021).Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis.CARBOHYDRATE POLYMERS,271,118443. |
| MLA | Zhang,Quanwei,et al."Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis".CARBOHYDRATE POLYMERS 271(2021):118443. |
入库方式： OAI收割
来源：昆明植物研究所
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