Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A
文献类型：期刊论文
| 作者 | Dai,Zhi; Liu,Hui; Wang,Bei; Yang,Dong; Zhu,Yan-Yan; Yan,Huan; Zhu,Pei-Feng; Liu,Ya-Ping; Chen,Hui-Cheng; Zhao,Yun-li |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 210页码:113068 |
| 关键词 | Steroidal saponins Structure-activity relationship Tribulosaponin A Glioma stem cells ROS SMALL MOLECULES CARDIAC-ARREST STEM-CELL IDENTIFICATION THERAPY BRAIN OPPORTUNITIES GLIOMA TUMORS NOX2 |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2020.113068 |
| 英文摘要 | Glioblastoma multiform (GBM) is the highly aggressive brain tumor with poor prognosis. Glioma stem cells (GSCs), small population of cancer cells that exist in GBM tissues, resistant to chemotherapy and radiotherapy and usually driving GBM recurrence, have been developed as effective therapeutic target. Steroidal saponins are one of important resources for anti-tumor agent and may be benefited to selectively clear GSCs. In this report, total of 97 natural steroidal saponins were investigated the relationship among structures/cytotoxicity/selectivity against GSCs, glioma cell lines and human untransformed cells, and revealed that tribulosaponin A was the most potent compound. Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-L-cysteine (NAC) clearing ROS delayed GSCs apoptosis. Besides, tribulosaponin A damaged GSCs recapturing tumor spheres formation. (C) 2020 Elsevier Masson SAS. All rights reserved. |
| WOS记录号 | WOS:000604903800047 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73417]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chen, Hui-Cheng 2.[Dai, Zhi 3.Zhu, Yan-Yan 4.Zhao, Yun-li 5.Zhao, Li-Xing 6.Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China 7.[Liu, Hui 8.Wang, Bei 9.Yan, Huan 10.Zhu, Pei-Feng |
| 推荐引用方式 GB/T 7714 | Dai,Zhi,Liu,Hui,Wang,Bei,et al. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2021,210:113068. |
| APA | Dai,Zhi.,Liu,Hui.,Wang,Bei.,Yang,Dong.,Zhu,Yan-Yan.,...&Luo,Xiao-Dong.(2021).Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,210,113068. |
| MLA | Dai,Zhi,et al."Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 210(2021):113068. |
入库方式： OAI收割
来源：昆明植物研究所
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