C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum
文献类型：期刊论文
| 作者 | Yuan,Hai-Lian; Zhao,Yun-Li; Hu,Kun ; He,Ying-Jie; Yang,Xing-Wei; Luo,Xiao-Dong
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 86期号:23页码:16764-16769 |
| 关键词 | OPIUM POPPY BIOSYNTHESIS APORPHINE TETRANDRINE PAPAVERINE DISCOVERY |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.1c01990 |
| 英文摘要 | Hyperectumine (1), the first C-19 benzylisoquinoline alkaloid with a complicated ring system, was isolated from Hypecoum erectum and structurally characterized. Its biosynthetic origin should involve a hybrid pattern of C-8 + C-8 + C-1 + C-2, from which a C-17 benzylisoquinoline alkaloid might be further attacked by a malonamic acid and undergo decarboxylation and cyclization to produce 1. Compound (-)-1 exhibited moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells. |
| WOS记录号 | WOS:000752848600045 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73428]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China 2.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China 3.He, Ying-Jie 4.[Yuan, Hai-Lian 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 6.Hu, Kun 7.[Zhao, Yun-Li |
| 推荐引用方式 GB/T 7714 | Yuan,Hai-Lian,Zhao,Yun-Li,Hu,Kun,et al. C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(23):16764-16769. |
| APA | Yuan,Hai-Lian,Zhao,Yun-Li,Hu,Kun,He,Ying-Jie,Yang,Xing-Wei,&Luo,Xiao-Dong.(2021).C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum.JOURNAL OF ORGANIC CHEMISTRY,86(23),16764-16769. |
| MLA | Yuan,Hai-Lian,et al."C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum".JOURNAL OF ORGANIC CHEMISTRY 86.23(2021):16764-16769. |
入库方式： OAI收割
来源：昆明植物研究所
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