Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus
文献类型：期刊论文
| 作者 | Zhu,Pei-Feng; Cheng,Gui-Guang; Zhao,Lan-Qin; Khan,Afsar; Yang,Xing-Wei ; Zhang,Bu-Yun; Li,Meng-Cheng; Liu,Ya-Ping; Luo,Xiao-Dong
|
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 69期号:22页码:6229-6239 |
| 关键词 | Rhynchanthus beesianus diarylheptanoid antioxidant activity intracellular reactive oxygen species cell apoptosis GINGER ZINGIBER-OFFICINALE PC12 CELLS RHIZOMES NEUROPROTECTION ACTIVATION ENZYMES L. |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.1c00869 |
| 英文摘要 | Rhynchanthus beesianus (Zingiberaceae) has been an important food spice and vegetable in southern China. Fifteen phenolic compounds (1-15) including three new diarylheptanoids, rhynchanines A-C (1-3) and one new phenylpropanoid, 4-O-methylstroside B (9), were isolated from R. beesianus rhizomes. The structures of new compounds were elucidated by comprehensive analyses through NMR, HRMS technique, acid hydrolysis, and Mosher's reaction. Among them, compound 5 is the first isolated natural product and its NMR data are reported. Most of the isolated compounds, especially 3-6 and 8, showed significant antioxidant activities on DPPH, ABTS(+) radical scavenging, and FRAP assays. Furthermore, the antioxidant phenolic compounds were evaluated for their cytoprotective capacity against H2O2 -induced oxidative stress in HepG-2 cells. Compounds 3 and 5 could significantly inhibit reactive oxygen species production, and compounds 3, 5, and 6 could remarkably prevent the cell apoptosis. Then, the R. beesianus rhizome, which contained phenolic compounds, might serve as a functional food for potential application on preventing oxidative stress-connected diseases. |
| WOS记录号 | WOS:000662082500011 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73447]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Kunming Univ Sci & Technol, Fac Agr & Food, Kunming 650500, Yunnan, Peoples R China 4.COMSATS Univ Islamabad, Dept Chem, Abbottabad 22060, Pakistan 5.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu,Pei-Feng,Cheng,Gui-Guang,Zhao,Lan-Qin,et al. Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2021,69(22):6229-6239. |
| APA | Zhu,Pei-Feng.,Cheng,Gui-Guang.,Zhao,Lan-Qin.,Khan,Afsar.,Yang,Xing-Wei.,...&Luo,Xiao-Dong.(2021).Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,69(22),6229-6239. |
| MLA | Zhu,Pei-Feng,et al."Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69.22(2021):6229-6239. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。