Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives
文献类型：期刊论文
| 作者 | Luo,Han; Lv,Yong-Feng; Zhang,Hong; Hu,Jiang-Miao; Li,Hong-Mei; Liu,Shou-Jin |
| 刊名 | MOLECULES
 |
| 出版日期 | 2021 |
| 卷号 | 26期号:11页码:3249 |
| 关键词 | mollugin triazoles antitumor activity synthesis ANTIMICROBIAL ACTIVITY RUBIA-CORDIFOLIA MOLLUGIN DESIGN ANALOGS BIOEVALUATION GLYCOSIDES APOPTOSIS AZIDES |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules26113249 |
| 英文摘要 | A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines. |
| WOS记录号 | WOS:000660474600001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73454]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.[Lv, Yong-Feng 2.Hu, Jiang-Miao 3.Anhui Univ Chinese Med, Coll Pharm, Hefei 230011, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Zhang, Hong 6.[Luo, Han |
| 推荐引用方式 GB/T 7714 | Luo,Han,Lv,Yong-Feng,Zhang,Hong,et al. Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives[J]. MOLECULES,2021,26(11):3249. |
| APA | Luo,Han,Lv,Yong-Feng,Zhang,Hong,Hu,Jiang-Miao,Li,Hong-Mei,&Liu,Shou-Jin.(2021).Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives.MOLECULES,26(11),3249. |
| MLA | Luo,Han,et al."Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives".MOLECULES 26.11(2021):3249. |
入库方式： OAI收割
来源：昆明植物研究所
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