Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection
文献类型：期刊论文
| 作者 | He,Yingying; He,Zhicheng; Leone,Serena; Liu,Shubai |
| 刊名 | NUTRIENTS
 |
| 出版日期 | 2021 |
| 卷号 | 13期号:9页码:3198 |
| 关键词 | HMOs exosome mucosal immunity 2 '-FL macrophages INTESTINAL HOMEOSTASIS MECHANISM VESICLES RECEPTOR CELLS |
| ISSN号 | 2072-6643 |
| DOI | 10.3390/nu13093198 |
| 英文摘要 | Exosomes are abundance in human body fluids like urine, milk and blood. They act a critical role in extracellular and intracellular communication, intracellular trafficking and physiological regulation. Multiple immune-modulatory components, such as proteins, RNAs and carbohydrates (glycoproteins), have been found in human milk exosomes, which play immune-regulatory functions. However, little is known about oligosaccharides in milk exosomes, the free sugars, which act critical roles in the development of infant's immature mucosal immune system. In this study, the profile of milk exosomes encapsulated human milk oligosaccharides (HMOs) was calibrated with characteristic oligosaccharides in colostrum and mature milk, respectively. The exosomes containing human milk oligosaccharides were uptaken by macrophages, which were responsible for the establishment of intestinal immunity. Furthermore, mice pretreated with exosome encapsulated HMOs were protected from AIEC infection and had significantly less LPS-induced inflammation and intestinal damage. Exosome encapsulated milk oligosaccharides are regarded to provide a natural manner for milk oligosaccharides to accomplish their critical functions in modifying newborn innate immunity. The understanding of the interaction between a mother's breastfeeding and the development of an infant's mucosal immune system would be advantageous. The transport of milk oligosaccharides to its target via exosome-like particles appears to be promising. |
| WOS记录号 | WOS:000700141000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73456]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Naples Federico II, Dept Chem Sci, I-80121 Naples, Italy 5.Stn Zool Anton Dohrn, Dipartimento Biol Evoluz Organismi Marini BEOM, Villa Communale, I-80121 Naples, Italy |
| 推荐引用方式 GB/T 7714 | He,Yingying,He,Zhicheng,Leone,Serena,et al. Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection[J]. NUTRIENTS,2021,13(9):3198. |
| APA | He,Yingying,He,Zhicheng,Leone,Serena,&Liu,Shubai.(2021).Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection.NUTRIENTS,13(9),3198. |
| MLA | He,Yingying,et al."Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection".NUTRIENTS 13.9(2021):3198. |
入库方式： OAI收割
来源：昆明植物研究所
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