Regulation of the Development in Physcomitrium (Physcomitrella) patens implicates the functional differentiation of plant RNase H1s
文献类型：期刊论文
| 作者 | Chen,Silin; Dong,Xiumei; Yang,Zhuo; Hou,Xin; Liu,Li
|
| 刊名 | PLANT SCIENCE
 |
| 出版日期 | 2021 |
| 卷号 | 313页码:111070 |
| 关键词 | Physcomitrium patens Plant development RNase H1 Auxin R-loop R-LOOP FORMATION GC SKEW MITOCHONDRIAL |
| ISSN号 | 0168-9452 |
| DOI | 10.1016/j.plantsci.2021.111070 |
| 英文摘要 | R-loops, consisting of a DNA:RNA hybrid and a single-stranded DNA (ssDNA), form naturally as functional chromosome structures and are crucial in many vital biological processes. However, disrupted R-loop homeo-stasis will threat to the integrity and stability of genome. As the endonuclease, RNase H1 can efficiently recognize and remove excess R-loops to protect organisms from DNA damage induced by R-loop over-accumulation. Here, we investigated the function of RNase H1 in Physcomitrium (Physcomitrella) patens to illustrate its important role in the evolution of plants. We found that PpRNH1A dysfunction seriously affected shoot growth and branch formation in P. patens, revealing a noticeable functional difference between PpRNH1A and AtRNH1A of Arabi-dopsis. Furthermore, auxin signaling was significantly affected at the transcriptional level in PpRNH1A mutant plants, as a result of the accumulation of R-loops at several auxin-related genes. This study provides evidence that PpRNH1A regulates the development of P. patens by controlling R-loop formation at specific loci to modulate the transcription of auxin-related genes. It also highlights the interspecific functional differences between early land plants and vascular plants, despite crucial and conserved role of RNase H1 played in maintaining R-loop homeostasis. |
| WOS记录号 | WOS:000709990700006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73464]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Hubei Univ, Hubei Collaborat Innovat Ctr Green Transformat Bi, Sch Life Sci, State Key Lab Biocatalysis & Enzyme Engn,Hubei Ke, Wuhan 430062, Peoples R China 4.Wuhan Univ, Coll Life Sci, State Key Lab Hybrid Rice, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen,Silin,Dong,Xiumei,Yang,Zhuo,et al. Regulation of the Development in Physcomitrium (Physcomitrella) patens implicates the functional differentiation of plant RNase H1s[J]. PLANT SCIENCE,2021,313:111070. |
| APA | Chen,Silin,Dong,Xiumei,Yang,Zhuo,Hou,Xin,&Liu,Li.(2021).Regulation of the Development in Physcomitrium (Physcomitrella) patens implicates the functional differentiation of plant RNase H1s.PLANT SCIENCE,313,111070. |
| MLA | Chen,Silin,et al."Regulation of the Development in Physcomitrium (Physcomitrella) patens implicates the functional differentiation of plant RNase H1s".PLANT SCIENCE 313(2021):111070. |
入库方式： OAI收割
来源：昆明植物研究所
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