Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects
文献类型：期刊论文
| 作者 | Yan,Huan; Li,Xiang; Ni,Wei; Zhao,Qing; Leng,Ying; Liu,Hai-Yang
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2021 |
| 卷号 | 18期号:1 |
| 关键词 | Cyclocarya paliurus dammarane-type triterpenoid saponins 11β -HSD1 enzyme inhibitory activity ANTIOXIDANT ACTIVITIES CHEMICAL-CONSTITUENTS DEHYDROGENASE TYPE-1 TRITERPENOIDS POLYSACCHARIDE SAPONINS |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202000772 |
| 英文摘要 | Two new dammarane-type triterpenoid saponins, 3 beta-(alpha-l-arabinopyranosyloxy)-24,25-dihydroxydammar-20-en-12 alpha-yl 6-deoxy-beta-d-glucopyranoside (1) and (24R)-3 beta-[(4-O-acetyl-alpha-l-arabinopyranosyl)oxy]-25-hydroxy-20,24-epoxydammaran-12 beta-yl 6-deoxy-beta-d-glucopyranoside (2), and fourteen known triterpenoids were isolated from the 70 % MeOH extract of the leaves of Cyclocarya paliurus. Their structures were established based on analyses of spectroscopic data. All compounds were tested for their inhibitory activities against the 11 beta-HSD1 enzyme. Hederagenin (13) exhibited moderate inhibitory effect for mouse 11 beta-HSD1 with an IC50 value of 0.16 +/- 0.04 mu M. |
| WOS记录号 | WOS:000602674800001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73468]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Yunnan Univ Chinese Med, Kunming 650500, Yunnan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan,Huan,Li,Xiang,Ni,Wei,et al. Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects[J]. CHEMISTRY & BIODIVERSITY,2021,18(1). |
| APA | Yan,Huan,Li,Xiang,Ni,Wei,Zhao,Qing,Leng,Ying,&Liu,Hai-Yang.(2021).Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects.CHEMISTRY & BIODIVERSITY,18(1). |
| MLA | Yan,Huan,et al."Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects".CHEMISTRY & BIODIVERSITY 18.1(2021). |
入库方式： OAI收割
来源：昆明植物研究所
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