Hypermonones A-I, New Polyprenylated Acylphloroglucinols from Hypericum monogynum with Multidrug Resistance Reversal Activity
文献类型：期刊论文
| 作者 | Zeng,Yan-Rong; Li,Ya-Nan; Yang,Jue; Yi,Ping; Huang,Lei; Huang,Lie-Jun; Gu,Wei ; Hu,Zhan-Xing; Li,Yan-Mei; Yuan,Chun-Mao
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 39期号:9页码:2422-2432 |
| 关键词 | Hypericum monogynum Phytochemistry Structure elucidation Biological activity Multidrug resistance reversal activity P-GLYCOPROTEIN MODULATORS CANCER |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202100210 |
| 英文摘要 | Main observation and conclusion Eleven biogenetically related polyprenylated acylphloroglucinols (PPAPs), including four novel skeletons (1-4) and five new compounds (5-9), were isolated from the flowers of Hypericum monogynum. Hypermonones A-D (1-4) represented the first example of a unique dilactone structure containing carbonyl bonded single delta-lactone and tricyclic gamma-lactone moieties. Their structures were elucidated by NMR analysis, X-ray crystallography, and ECD calculations. Moreover, we revised the structure of hyperibrin B to hypermonone I (9) via NMR analysis, a quantum computational chemistry method, and hypothetic biosynthetic considerations. Three compounds (5, 6, and 9) with significant MDR reversal activity (RF ranging from 61 to 223) were superior to the positive control verapamil (MCF-7/ADR, RF: 53; HepG2/ADR, RF: 124). Mechanism study for compound 5 indicated that this compound could inhibit the function of P-gp transport rather than its expression, and the possible recognition mechanism between compound 5 and P-gp was predicted by molecular docking. |
| WOS记录号 | WOS:000676096000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73492]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.[Zeng, Yan-Rong 2.Yuan, Chun-Mao 3.Gu, Wei 4.Yang, Jue 5.Li, Ya-Nan 6.Hu, Zhan-Xing 7.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China 8.Key Lab Chem & Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China 9.Chinese Acad Sci, Guiyang 550014, Guizhou, Peoples R China 10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng,Yan-Rong,Li,Ya-Nan,Yang,Jue,et al. Hypermonones A-I, New Polyprenylated Acylphloroglucinols from Hypericum monogynum with Multidrug Resistance Reversal Activity[J]. CHINESE JOURNAL OF CHEMISTRY,2021,39(9):2422-2432. |
| APA | Zeng,Yan-Rong.,Li,Ya-Nan.,Yang,Jue.,Yi,Ping.,Huang,Lei.,...&Hao,Xiao-Jiang.(2021).Hypermonones A-I, New Polyprenylated Acylphloroglucinols from Hypericum monogynum with Multidrug Resistance Reversal Activity.CHINESE JOURNAL OF CHEMISTRY,39(9),2422-2432. |
| MLA | Zeng,Yan-Rong,et al."Hypermonones A-I, New Polyprenylated Acylphloroglucinols from Hypericum monogynum with Multidrug Resistance Reversal Activity".CHINESE JOURNAL OF CHEMISTRY 39.9(2021):2422-2432. |
入库方式： OAI收割
来源：昆明植物研究所
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