Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis
文献类型：期刊论文
| 作者 | Jing,Shu-Xi; Fu,Ran; Li,Chun-Huan; Zhou,Ting-Ting; Liu,Yan-Chun; Liu,Yan; Luo,Shi-Hong; Li,Xiao-Nian; Zeng,Fang; Li,Sheng-Hong
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 86期号:16页码:11169-11176 |
| 关键词 | LEUCOSCEPTRUM-CANUM GLANDULAR TRICHOMES PRODUCTS FAMILY HARBOR |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.1c00374 |
| 英文摘要 | A pair of new C-14 epimeric sesterterpenoids, colquhounoid D (1) and 14-epi-colquhounoid D (2), and five degradation products featuring new C-20 and C-21 frameworks, norcolquhounoids A-E (3-7), were isolated from Colquhounia coccinea var. mollis. Their structures were elucidated by comprehensive spectroscopic analysis and single-crystal X-ray diffraction. Degradation of the C-25 skeleton to the C-21 skeleton was also achieved using aqueous NaIO4 and RuCl3. Compounds 1 and 2 showed significant immunosuppressive activity on the cytokine IFN-gamma secretion of mouse splenocytes induced by anti-CD3/CD4 monoclonal antibodies, with IC50 of 8.38 and 5.79 mu M, respectively, and compounds 5 and 6 were moderately active. |
| WOS记录号 | WOS:000687851300023 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73510]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Teaching Hosp 3, Chengdu 611137, Peoples R China 4.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 5.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing,Shu-Xi,Fu,Ran,Li,Chun-Huan,et al. Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(16):11169-11176. |
| APA | Jing,Shu-Xi.,Fu,Ran.,Li,Chun-Huan.,Zhou,Ting-Ting.,Liu,Yan-Chun.,...&Li,Sheng-Hong.(2021).Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis.JOURNAL OF ORGANIC CHEMISTRY,86(16),11169-11176. |
| MLA | Jing,Shu-Xi,et al."Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis".JOURNAL OF ORGANIC CHEMISTRY 86.16(2021):11169-11176. |
入库方式： OAI收割
来源：昆明植物研究所
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