Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis
文献类型：期刊论文
| 作者 | Teng,Lin-Lin; Mu,Rong-Fang; Liu,Yan-Chun; Xiao,Chao-Jiang; Li,De-Sen; Gao,Jian-Xiong; Guo,Kai; Li,Xiao-Nian; Liu,Yan; Zeng,Fang |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 23期号:6页码:2232-2237 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c00369 |
| 英文摘要 | Eurysoloids A (1) and B (2), two novel diastereomeric sesterterpenoids possessing a pentacyclic 5/6/5/10/5 framework with an unusual macrocyclic ether system, were isolated from Eurysolen gracilis Frain. Their structures were unambiguously determined by spectroscopic, single-crystal X-ray diffraction and DP4+ analyses. A plausible biosynthetic pathway for compounds 1 and 2 was proposed. Both compounds exhibited immunosuppressive activity via inhibiting the production of cytokine IFN-gamma of T cells, and compound 2 inhibited adipogenesis in 3T3-L1 adipocytes. |
| WOS记录号 | WOS:000631439700052 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73511]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Dali Univ, Coll Pharm, Dali 671000, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Dali Univ, Inst Mat Med, Dali 671000, Peoples R China 6.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 7.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 8.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 611137, Peoples R China |
| 推荐引用方式 GB/T 7714 | Teng,Lin-Lin,Mu,Rong-Fang,Liu,Yan-Chun,et al. Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis[J]. ORGANIC LETTERS,2021,23(6):2232-2237. |
| APA | Teng,Lin-Lin.,Mu,Rong-Fang.,Liu,Yan-Chun.,Xiao,Chao-Jiang.,Li,De-Sen.,...&Li,Sheng-Hong.(2021).Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis.ORGANIC LETTERS,23(6),2232-2237. |
| MLA | Teng,Lin-Lin,et al."Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis".ORGANIC LETTERS 23.6(2021):2232-2237. |
入库方式： OAI收割
来源：昆明植物研究所
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