Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans
文献类型：期刊论文
| 作者 | Hua,Juan; Liu,Yan-Chun; Luo,Shi-Hong; Liu,Yan; Xiao,Chao-Jiang; Li,Xiao-Nian; Li,Sheng-Hong
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 23期号:19页码:7462-7466 |
| 关键词 | QUILLAJA-SAPONARIA BIOSYNTHESIS MECHANISMS ADJUVANTS VARIANTS PRODUCTS CYCLASE |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c02673 |
| 英文摘要 | Two novel triterpenoid saponins, colqueleganoids A (1) and B (2), with the first methyl-30 incorporated 6/6/6/6-cyclized carbon skeleton (named colquelegane), were isolated from the root of Colquhounia elegans. Their structures including absolute configuration were determined by spectroscopic methods and X-ray crystallographic analyses. Interestingly, both compounds significantly enhanced TNF-alpha production and 1 also increased the IL-6 production in RAW264.7 macrophages stimulated with lipopolysaccharide (LPS), suggesting their potential application as immunostimulants in immunotherapy and vaccination. |
| WOS记录号 | WOS:000704710800028 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73514]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Liu, Yan 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 4.[Hua, Juan 5.Luo, Shi-Hong 6.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 7.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 8.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Peoples R China 9.[Liu, Yan-Chun 10.Xiao, Chao-Jiang |
| 推荐引用方式 GB/T 7714 | Hua,Juan,Liu,Yan-Chun,Luo,Shi-Hong,et al. Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans[J]. ORGANIC LETTERS,2021,23(19):7462-7466. |
| APA | Hua,Juan.,Liu,Yan-Chun.,Luo,Shi-Hong.,Liu,Yan.,Xiao,Chao-Jiang.,...&Li,Sheng-Hong.(2021).Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans.ORGANIC LETTERS,23(19),7462-7466. |
| MLA | Hua,Juan,et al."Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans".ORGANIC LETTERS 23.19(2021):7462-7466. |
入库方式： OAI收割
来源：昆明植物研究所
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