中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans

文献类型:期刊论文

作者Hua,Juan; Liu,Yan-Chun; Luo,Shi-Hong; Liu,Yan; Xiao,Chao-Jiang; Li,Xiao-Nian; Li,Sheng-Hong
刊名ORGANIC LETTERS
出版日期2021
卷号23期号:19页码:7462-7466
关键词QUILLAJA-SAPONARIA BIOSYNTHESIS MECHANISMS ADJUVANTS VARIANTS PRODUCTS CYCLASE
ISSN号1523-7060
DOI10.1021/acs.orglett.1c02673
英文摘要Two novel triterpenoid saponins, colqueleganoids A (1) and B (2), with the first methyl-30 incorporated 6/6/6/6-cyclized carbon skeleton (named colquelegane), were isolated from the root of Colquhounia elegans. Their structures including absolute configuration were determined by spectroscopic methods and X-ray crystallographic analyses. Interestingly, both compounds significantly enhanced TNF-alpha production and 1 also increased the IL-6 production in RAW264.7 macrophages stimulated with lipopolysaccharide (LPS), suggesting their potential application as immunostimulants in immunotherapy and vaccination.
WOS记录号WOS:000704710800028
源URL[http://ir.kib.ac.cn/handle/151853/73514]  
专题中国科学院昆明植物研究所
作者单位1.Liu, Yan
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
4.[Hua, Juan
5.Luo, Shi-Hong
6.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
7.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China
8.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Peoples R China
9.[Liu, Yan-Chun
10.Xiao, Chao-Jiang
推荐引用方式
GB/T 7714
Hua,Juan,Liu,Yan-Chun,Luo,Shi-Hong,et al. Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans[J]. ORGANIC LETTERS,2021,23(19):7462-7466.
APA Hua,Juan.,Liu,Yan-Chun.,Luo,Shi-Hong.,Liu,Yan.,Xiao,Chao-Jiang.,...&Li,Sheng-Hong.(2021).Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans.ORGANIC LETTERS,23(19),7462-7466.
MLA Hua,Juan,et al."Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans".ORGANIC LETTERS 23.19(2021):7462-7466.

入库方式: OAI收割

来源:昆明植物研究所

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