Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity
文献类型：期刊论文
| 作者 | Guo,Kai; Zhou,Ting-Ting; Ren,Xue; Li,Dan; Hu,Hong ; Liu,Yan-Chun; Liu,Yan; Li,Sheng-Hong
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 192页码:112961 |
| 关键词 | Gentiana veitchiorum Gentianaceae Secoiridoids Triterpenoids Immunosuppressive activity CONSTITUENTS HEMSL. |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.112961 |
| 英文摘要 | Two undescribed secoiridoids (dehydroxyl-swerimilegenin H and 9-oxo-swerimuslactone A) with eight known ones, and two undescribed triterpenoids [28-O-(3,4-dihydroxyl-benzyl)-lupeol and 17-hydroperoxide-28-norurs12-en-3-one] with seven known ones, were isolated from the aerial parts of Gentiana veitchiorum, a traditional Tibetan medicine. The structures of these compounds were elucidated by detailed spectroscopic analyses (including 1D and 2D NMR, HRMS, IR, and specific rotation) and comparison with structurally related known compounds. The isolates were selected to evaluate for their immunosuppressive activity via inhibiting the proliferation of T cells and cytokine IFN-gamma production in T cells. Among them, 28-O-(3,4-dihydroxyl-benzyl)-lupeol exhibited significant effect by inhibiting the proliferation of T cells (IC50, 20.08 mu M) and T cell IFN-gamma production (IC50, 7.29 mu M). |
| WOS记录号 | WOS:000704441000014 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73516]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 2.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 3.Hu, Hong 4.Liu, Yan 5.[Guo, Kai 6.Ren, Xue 7.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 8.[Zhou, Ting-Ting 9.Li, Dan 10.Liu, Yan-Chun |
| 推荐引用方式 GB/T 7714 | Guo,Kai,Zhou,Ting-Ting,Ren,Xue,et al. Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2021,192:112961. |
| APA | Guo,Kai.,Zhou,Ting-Ting.,Ren,Xue.,Li,Dan.,Hu,Hong.,...&Li,Sheng-Hong.(2021).Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity.PHYTOCHEMISTRY,192,112961. |
| MLA | Guo,Kai,et al."Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity".PHYTOCHEMISTRY 192(2021):112961. |
入库方式： OAI收割
来源：昆明植物研究所
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