Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum
文献类型：期刊论文
| 作者 | Guo,Kai; Liu,Yan-Chun; Liu,Yan; Zhang,Han; Li,Wen-Yuan; Shi,Qiu-Mei; Li,Xiao-Nian; Zeng,Fang; Li,Sheng-Hong
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 187页码:112780 |
| 关键词 | Gentianella turkestanorum Gentianaceae Plant sesterterpenoids Gentianellane-type Immunosuppressive activity GLANDULAR TRICHOMES LEUCOSCEPTRUM-CANUM CONSTITUENTS PRODUCTS HARBOR |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.112780 |
| 英文摘要 | Whole plants of Gentianella turkestanorum are commonly used as a traditional Uighur medicine. A phytochemical investigation led to the isolation of eight undescribed gentianellane-type sesterterpenoids (18-epi-nitidasin, gentianelloids D-F, and 18-epi-gentianelloids C-F), one undescribed 11,12-seco-gentianellane (18-epi-alborosin), and three known analogs (nitidasin, gentianelloid C and alborosin) among which gentianelloid C was found for the first time from a natural source. The structures of these compounds were elucidated by extensive spectroscopic analyses (including 1D and 2D NMR, HRMS, IR, and specific rotation) and in the case of 18-epi-gentianelloid C by the single-crystal X-ray diffraction analysis. A putative biosynthetic route for these sesterterpenoids was proposed. The immunosuppressive activity of the isolated compounds was also evaluated by their ability to inhibit the proliferation of T cells and T cell cytokine IFN-gamma production. Nitidasin suppressed IFN-gamma production with an IC50 value of 16.50 mu M, while gentianelloid F and alborosin inhibited the proliferation of and IFN-gamma production in T cells with IC50 values of 12.40-14.66 mu M. |
| WOS记录号 | WOS:000654130400029 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73518]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Li, Xiao-Nian 2.[Guo, Kai 3.Liu, Yan 4.Zeng, Fang 5.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 6.[Liu, Yan-Chun 7.Zhang, Han 8.Li, Wen-Yuan 9.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 10.Wuyi Univ, Coll Tea & Food Technol, Wuyishan 354300, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo,Kai,Liu,Yan-Chun,Liu,Yan,et al. Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum[J]. PHYTOCHEMISTRY,2021,187:112780. |
| APA | Guo,Kai.,Liu,Yan-Chun.,Liu,Yan.,Zhang,Han.,Li,Wen-Yuan.,...&Li,Sheng-Hong.(2021).Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum.PHYTOCHEMISTRY,187,112780. |
| MLA | Guo,Kai,et al."Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum".PHYTOCHEMISTRY 187(2021):112780. |
入库方式： OAI收割
来源：昆明植物研究所
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