FXR activation prevents liver injury induced by Tripterygium wilfordii preparations
文献类型：期刊论文
| 作者 | Peng,Wan ; Dai,Man-Yun; Bao,Li-Juan; Zhu,Wei-Feng; Li,Fei
|
| 刊名 | XENOBIOTICA
 |
| 出版日期 | 2021 |
| 卷号 | 51期号:6页码:716-727 |
| 关键词 | Tripterygium wilfordii liver injury farnesoid X receptor bile acid metabolism metabolomics |
| ISSN号 | 0049-8254 |
| DOI | 10.1080/00498254.2021.1900626 |
| 英文摘要 | Tripterygium glycosides tablets (TGT) and Tripterygium wilfordii tablets (TWT) are the preparations of Tripterygium wilfordii used to treat rheumatoid arthritis (RA) in the clinic, but the hepatotoxicity was reported frequently. This study aimed to determine the potential toxicity mechanism of liver injury induced by the preparations of Tripterygium wilfordii in mice.Here, we performed metabolomic analysis, pathological analysis and biochemical analysis of samples from mice with liver injury induced by TGT and TWT, which revealed that liver injury was associated with bile acid metabolism disorder. Quantitative real-time PCR (QPCR) and western blot indicated that the above changes were accompanied by inhibition of farnesoid X receptor (FXR) signalling.Liver injury from TWT could be alleviated by treatment of the FXR agonist obeticholic acid (OCA) via activation of the FXR to inhibit the c-Jun N-terminal kinase (JNK) pathway and improve bile acid metabolism disorder by activating bile salt export pump (BSEP) and organic solute-transporter-beta (OSTB). The data demonstrate that FXR signalling pathway plays a key role in T. wilfordii-induced liver injury, which could be alleviated by activated FXR.These results indicate that FXR activation by OCA may offer a promising therapeutic opportunity against hepatotoxicity from the preparations of T. wilfordii. |
| WOS记录号 | WOS:000635403000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73529]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.[Peng, Wan 3.Dai, Man-Yun 4.Bao, Li-Juan 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 6.Sichuan Univ, West China Hosp, Lab Metabol & Drug Induced Liver Injury, Frontiers Sci Ctr Dis Related Mol Network, Chengdu 610065, Peoples R China 7.Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian, Shaanxi, Peoples R China 8.Jiangxi Univ Tradit Chinese Med, Academician Workstn, Nanchang, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng,Wan,Dai,Man-Yun,Bao,Li-Juan,et al. FXR activation prevents liver injury induced by Tripterygium wilfordii preparations[J]. XENOBIOTICA,2021,51(6):716-727. |
| APA | Peng,Wan,Dai,Man-Yun,Bao,Li-Juan,Zhu,Wei-Feng,&Li,Fei.(2021).FXR activation prevents liver injury induced by Tripterygium wilfordii preparations.XENOBIOTICA,51(6),716-727. |
| MLA | Peng,Wan,et al."FXR activation prevents liver injury induced by Tripterygium wilfordii preparations".XENOBIOTICA 51.6(2021):716-727. |
入库方式： OAI收割
来源：昆明植物研究所
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