Polyamine metabolism links gut microbiota and testicular dysfunction
文献类型：期刊论文
| 作者 | Zhao,Qi ; Huang,Jian-Feng; Cheng,Yan; Dai,Man-Yun; Zhu,Wei-Feng; Yang,Xiu-Wei; Gonzalez,Frank J.; Li,Fei
|
| 刊名 | MICROBIOME
 |
| 出版日期 | 2021 |
| 卷号 | 9期号:1页码:224 |
| 关键词 | Testicular dysfunction Gut microbiota Polyamine metabolism Metabolomics SMALL-MOLECULE INHIBITOR ORNITHINE-DECARBOXYLASE TRIPTOLIDE SPERMINE ACTIVATION DISRUPTION MECHANISMS EXPRESSION APOPTOSIS TRANSPORT |
| ISSN号 | 2049-2618 |
| DOI | 10.1186/s40168-021-01157-z |
| 英文摘要 | Background: Male fertility impaired by exogenous toxins is a serious worldwide issue threatening the health of the new-born and causing infertility. However, the metabolic connection between toxic exposures and testicular dysfunction remains unclear.Results: In the present study, the metabolic disorder of testicular dysfunction was investigated using triptolide-induced testicular injury in mice. We found that triptolide induced spermine deficiency resulting from disruption of polyamine biosynthesis and uptake in testis, and perturbation of the gut microbiota. Supplementation with exogenous spermine reversed triptolide-induced testicular dysfunction through increasing the expression of genes related to early and late spermatogenic events, as well as increasing the reduced number of offspring. Loss of gut microbiota by antibiotic treatment resulted in depletion of spermine levels in the intestine and potentiation of testicular injury. Testicular dysfunction in triptolide-treated mice was reversed by gut microbial transplantation from untreated mice and supplementation with polyamine-producing Parabacteroides distasonis. The protective effect of spermine during testicular injury was largely dependent on upregulation of heat shock protein 70s (HSP70s) both in vivo and in vitro.Conclusions: The present study linked alterations in the gut microbiota to testicular dysfunction through disruption of polyamine metabolism. The diversity and dynamics of the gut microbiota may be considered as a therapeutic option to prevent male infertility. |
| WOS记录号 | WOS:000716997100002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73530]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China 2.[Zhao, Qi 3.Cheng, Yan 4.Dai, Man-Yun 5.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, State Key Lab Biotherapy, Chengdu 610041, Peoples R China 6.Huang, Jian-Feng 7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 8.Shanwei Inst Food & Drug Control, Shanwei 516622, Guangdong, Peoples R China 9.Jiangxi Univ Tradit Chinese Med, Academician Workstn, Nanchang 330004, Jiangxi, Peoples R China 10.[Gonzalez, Frank J.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA |
| 推荐引用方式 GB/T 7714 | Zhao,Qi,Huang,Jian-Feng,Cheng,Yan,et al. Polyamine metabolism links gut microbiota and testicular dysfunction[J]. MICROBIOME,2021,9(1):224. |
| APA | Zhao,Qi.,Huang,Jian-Feng.,Cheng,Yan.,Dai,Man-Yun.,Zhu,Wei-Feng.,...&Li,Fei.(2021).Polyamine metabolism links gut microbiota and testicular dysfunction.MICROBIOME,9(1),224. |
| MLA | Zhao,Qi,et al."Polyamine metabolism links gut microbiota and testicular dysfunction".MICROBIOME 9.1(2021):224. |
入库方式： OAI收割
来源：昆明植物研究所
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