Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll-like receptor-4 via NF-kappa B pathway
文献类型：期刊论文
| 作者 | Li,Long-Fei; Yue,Grace G-L; Chan,Ben C-L; Zeng,Qiang; Han,Quan-Bin; Leung,Ping-Chung; Fung,Kwok-Pui; Liu,Ji-Kai; Lau,Clara B-S |
| 刊名 | PHYTOTHERAPY RESEARCH
 |
| 出版日期 | 2021 |
| 卷号 | 35期号:4页码:2108-2118 |
| 关键词 | immunostimulatory effects immunosuppression myelosuppression polysaccharide Rubinoboletus ballouii toll‐ like receptor‐ 4 GANODERMA-LUCIDUM DENDRITIC CELLS IN-VITRO ANTITUMOR MUSHROOMS |
| ISSN号 | 0951-418X |
| DOI | 10.1002/ptr.6958 |
| 英文摘要 | The biological activities of water-soluble components of edible mushroom Rubinoboletus ballouii (RB) were seldom reported. Polysaccharides of RB (RBP) were prepared and well-characterized using chemical analyses. The immunomodulatory properties of RBP were investigated using human monocyte-derived dendritic cells (moDC) in vitro, and cyclophosphamide (CTX)-induced immunosuppressive mouse model. Results showed that RBP was found to contain 80.6% (w/w) of neutral sugars including D-fucose, D-mannose, D-glucose and D-galactose (1.7:1.4:1.0:1.8), and 12.5% (w/w) of proteins, which composed of glutamine, threonine, serine, etc. RBP could promote the maturation of moDC and increase the secretion of IL-12p40, IL-10, and TNF-alpha. Furthermore, the stimulation of IL-12p40 production was inhibited by pretreatment with toll-like receptor (TLR)-4 blocker or NF-kappa B pathway blocker, suggesting that the activation of moDC by RBP was mediated through NF-kappa B pathway via TLR-4 receptor. On the other hand, in CTX-treated mice, RBP restored the loss of CD34(bright)CD45(dim) hematopoietic stem cells and increased IL-2 production in sera and splenocytes culture supernatant, as well as up-regulated the percentage of CD4(+) T helper lymphocyte in mice splenocytes. These findings strongly suggested that RBP are the active ingredients of RB responsible for its immunostimulatory actions and deserved to be further investigated as cancer supplements. |
| WOS记录号 | WOS:000591447400001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73552]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Shenzhen Zhongshan Urol Hosp, Shenzhen Zhongshan Inst Reprod & Genet, Shenzhen Key Lab Reprod Immunol Peri Implantat, Shenzhen, Peoples R China 2.Chinese Univ Hong Kong, State Key Lab Res Bioact & Clin Applicat Med Plan, Shatin, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China 4.Fung, Kwok-Pui 5.Leung, Ping-Chung 6.Zeng, Qiang 7.Chan, Ben C-L 8.Yue, Grace G-L 9.[Li, Long-Fei 10.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li,Long-Fei,Yue,Grace G-L,Chan,Ben C-L,et al. Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll-like receptor-4 via NF-kappa B pathway[J]. PHYTOTHERAPY RESEARCH,2021,35(4):2108-2118. |
| APA | Li,Long-Fei.,Yue,Grace G-L.,Chan,Ben C-L.,Zeng,Qiang.,Han,Quan-Bin.,...&Lau,Clara B-S.(2021).Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll-like receptor-4 via NF-kappa B pathway.PHYTOTHERAPY RESEARCH,35(4),2108-2118. |
| MLA | Li,Long-Fei,et al."Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll-like receptor-4 via NF-kappa B pathway".PHYTOTHERAPY RESEARCH 35.4(2021):2108-2118. |
入库方式： OAI收割
来源：昆明植物研究所
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