Bisaspochalasins D and E: Two Heterocycle-Fused Cytochalasan Homodimers from an Endophytic Aspergillus flavipes
文献类型：期刊论文
| 作者 | Wang,Li ; Yu,Zhiyin; Guo,Xiaowei; Huang,Jian-Ping; Yan,Yijun; Huang,Sheng-Xiong; Yang,Jing
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 86期号:16页码:11198-11205 |
| ISSN号 | 0022-3263 |
| 关键词 | A-D ALKALOIDS MEROCYTOCHALASANS BIOSYNTHESIS SKELETON DIMER |
| DOI | 10.1021/acs.joc.1c00425 |
| 英文摘要 | Two heterocycle-fused cytochalasan homodimers, bisaspochalasins D (1) and E (2), were isolated from an endophytic Aspergillus flavipes. Their chemical structures were elucidated using a combination of HRESIMS, NMR, theoretical calculations, and crystallographic techniques. Bisaspochalasin D (1) is dimerized by the first reported naturally occurring triple heterobridged 3,8-dioxa-6-azabicyclo[3.2.1]octane framework, while bisaspochalasin E (2) employs a pyrrole ring as the linking moiety. Possible dimerization mechanisms of bisaspochalasins D and E were proposed. The bioassay screening revealed that bisaspochalasin D showed cytotoxic activities against five cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) with IC50 values ranging from 4.45 to 22.99 mu M. Additionally, bisaspochalasin D exhibited neurotrophic activities in a PC12 cell-based assay. At a concentration of 10 mu M, bisaspochalasin D can promote neurite growth by inducing a differentiation rate of 12.52% for PC12 cells. |
| WOS记录号 | WOS:000687851300026 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73625]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Huang, Sheng-Xiong 2.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 3.Yan, Yijun 4.[Wang, Li 5.Guo, Xiaowei 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 7.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, Kunming 650201, Yunnan, Peoples R China 8.Yu, Zhiyin 9.Huang, Jian-Ping |
| 推荐引用方式 GB/T 7714 | Wang,Li,Yu,Zhiyin,Guo,Xiaowei,et al. Bisaspochalasins D and E: Two Heterocycle-Fused Cytochalasan Homodimers from an Endophytic Aspergillus flavipes[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(16):11198-11205. |
| APA | Wang,Li.,Yu,Zhiyin.,Guo,Xiaowei.,Huang,Jian-Ping.,Yan,Yijun.,...&Yang,Jing.(2021).Bisaspochalasins D and E: Two Heterocycle-Fused Cytochalasan Homodimers from an Endophytic Aspergillus flavipes.JOURNAL OF ORGANIC CHEMISTRY,86(16),11198-11205. |
| MLA | Wang,Li,et al."Bisaspochalasins D and E: Two Heterocycle-Fused Cytochalasan Homodimers from an Endophytic Aspergillus flavipes".JOURNAL OF ORGANIC CHEMISTRY 86.16(2021):11198-11205. |
入库方式： OAI收割
来源：昆明植物研究所
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