Tropane alkaloid biosynthesis: a centennial review
文献类型：期刊论文
| 作者 | Huang,Jian-Ping; Wang,Yong-Jiang; Tian,Tian; Wang,Li ; Yan,Yijun; Huang,Sheng-Xiong
|
| 刊名 | NATURAL PRODUCT REPORTS
 |
| 出版日期 | 2021 |
| 卷号 | 38期号:9页码:1634-1658 |
| 关键词 | PUTRESCINE N-METHYLTRANSFERASE TRANSFORMED ROOT CULTURES 2 TROPINONE REDUCTASES ROLLE DES ACETATS DATURA-STRAMONIUM HYOSCYAMUS-NIGER TOBACCO ALKALOIDS ORNITHINE-DECARBOXYLASE 2-OXOGLUTARATE-DEPENDENT DIOXYGENASE DIFFERENT STEREOSPECIFICITIES |
| ISSN号 | 0265-0568 |
| DOI | 10.1039/d0np00076k |
| 英文摘要 | Covering: 1917 to 2020 Tropane alkaloids (TAs) are a remarkable class of plant secondary metabolites, which are characterized by an 8-azabicyclo[3.2.1]octane (nortropane) ring. Members of this class, such as hyoscyamine, scopolamine, and cocaine, are well known for their long history as poisons, hallucinogens, and anaesthetic agents. Since the structure of the tropane ring system was first elucidated in 1901, organic chemists and biochemists have been interested in how these mysterious tropane alkaloids are assembled in vitro and in vivo. However, it was only in 2020 that the complete biosynthetic route of hyoscyamine and scopolamine was clarified, and their de novo production in yeast was also achieved. The aim of this review is to present the innovative ideas and results in exploring the story of tropane alkaloid biosynthesis in plants from 1917 to 2020. This review also highlights that Robinson's classic synthesis of tropinone, which is one hundred years old, is biomimetic, and underscores the importance of total synthesis in the study of natural product biosynthesis. |
| WOS记录号 | WOS:000698386800007 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73626]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Tian, Tian 2.[Huang, Jian-Ping 3.Wang, Yong-Jiang 4.Wang, Li 5.Yan, Yijun 6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, CAS Ctr Excellence Mol Plant Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 7.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 8.[Tian, Tian 9.Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710119, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang,Jian-Ping,Wang,Yong-Jiang,Tian,Tian,et al. Tropane alkaloid biosynthesis: a centennial review[J]. NATURAL PRODUCT REPORTS,2021,38(9):1634-1658. |
| APA | Huang,Jian-Ping,Wang,Yong-Jiang,Tian,Tian,Wang,Li,Yan,Yijun,&Huang,Sheng-Xiong.(2021).Tropane alkaloid biosynthesis: a centennial review.NATURAL PRODUCT REPORTS,38(9),1634-1658. |
| MLA | Huang,Jian-Ping,et al."Tropane alkaloid biosynthesis: a centennial review".NATURAL PRODUCT REPORTS 38.9(2021):1634-1658. |
入库方式： OAI收割
来源：昆明植物研究所
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