Discovery and heterologous production of sarubicins and quinazolinone C-glycosides with protecting activity for cardiomyocytes
文献类型：期刊论文
| 作者 | Yu,Mingming; Luo,Jianying ; Luo,Dan; He,Qiang; Yan,Yijun; Ji,Xu; Huang,Sheng-Xiong
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2021 |
| 卷号 | 8期号:14页码:3829-3837 |
| 关键词 | STREPTOMYCES-VIOLACEORUBER TU22 BIOSYNTHESIS GRANATICIN ANTIBIOTICS METABOLISM MECHANISM PATHWAY ACID |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d1qo00470k |
| 英文摘要 | Glycosylated natural products and their derivatives are important pharmaceutical agents. Genome mining of a C-glycosylated metabolite biosynthetic gene cluster (BGC) from a soil-derived Streptomyces strain led to the isolation of sarubicins A (1) and B (2), of which 1 has a rare 2-oxabicyclo[2.2.2] substructure arising from C-glycosylation and C-C bond formation between the aglycone and the C-4 position of deoxysugar. Heterologous expression of the sar BGC led to the production of sarubicins and three new C-glycosylated quinazolinones 3-5 with a single C-C bond between the aglycone and deoxysugar, indicating the stepwise formation mechanism of the two unusual C-C bonds. A convenient chemical transformation from 1 to 2 and a proposed biosynthetic pathway for sarubicins are presented. Significantly, compounds 1 and 2 showed potent protective effects on neonatal rat cardiomyocytes. |
| WOS记录号 | WOS:000653846900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73627]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan key Lab Nat Med Chem, Kunming 650204, Yunnan, Peoples R China 3.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 5.Yunnan Univ Tradit Chinese Med, Coll Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu,Mingming,Luo,Jianying,Luo,Dan,et al. Discovery and heterologous production of sarubicins and quinazolinone C-glycosides with protecting activity for cardiomyocytes[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(14):3829-3837. |
| APA | Yu,Mingming.,Luo,Jianying.,Luo,Dan.,He,Qiang.,Yan,Yijun.,...&Huang,Sheng-Xiong.(2021).Discovery and heterologous production of sarubicins and quinazolinone C-glycosides with protecting activity for cardiomyocytes.ORGANIC CHEMISTRY FRONTIERS,8(14),3829-3837. |
| MLA | Yu,Mingming,et al."Discovery and heterologous production of sarubicins and quinazolinone C-glycosides with protecting activity for cardiomyocytes".ORGANIC CHEMISTRY FRONTIERS 8.14(2021):3829-3837. |
入库方式： OAI收割
来源：昆明植物研究所
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