Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases
文献类型：期刊论文
| 作者 | Ren,Fu-Cai; Liu,Li ; Lv,Yong-Feng; Bai,Xue; Kang,Qian-Jin; Hu,Xiao-Jing; Zhuang,Hong-Dan; Yang,Liu; Hu,Jiang-Miao; Zhou,Jun
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2021 |
| 卷号 | 84期号:2页码:417-426 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.0c01101 |
| 英文摘要 | Twelve hitherto unknown tandem prenylated p-hydroxybenzoic acid derivatives, namely, oberoniamyosurusins A-L, together with five known derivatives, were isolated from an EtOH extract of the whole parts of the plant Oberonia myosurus. Compounds 10, 13, and 17 exhibited moderate inhibitory activity against Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 values ranging from 7.6 to 23 mu g/mL. To determine the biosynthetic pathway of this class of tandem prenyl-substituted compounds, the full-length transcriptome of O. myosurus was sequenced, yielding 19.09 Gb of clean data and 10 949 nonredundant sequences. Two isoforms of p-hydroxybenzoic acid prenyltransferases were annotated and functionally characterized as the enzymes that might be involved in the biosynthesis of nervogenic acid (13) in Pichia pastoris. |
| WOS记录号 | WOS:000624549800023 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73639]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China 2.Zhuang, Hong-Dan 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.[Kang, Qian-Jin 5.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China 6.Bai, Xue 7.Lv, Yong-Feng 8.Liu, Li 9.[Ren, Fu-Cai 10.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren,Fu-Cai,Liu,Li,Lv,Yong-Feng,et al. Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(2):417-426. |
| APA | Ren,Fu-Cai.,Liu,Li.,Lv,Yong-Feng.,Bai,Xue.,Kang,Qian-Jin.,...&Zhou,Jun.(2021).Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases.JOURNAL OF NATURAL PRODUCTS,84(2),417-426. |
| MLA | Ren,Fu-Cai,et al."Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases".JOURNAL OF NATURAL PRODUCTS 84.2(2021):417-426. |
入库方式： OAI收割
来源：昆明植物研究所
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