The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels
文献类型：期刊论文
| 作者 | Fang,Chengchi; Gan,Xiaoni; Zhang,Chengjun ; He,Shunping
|
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2021 |
| 卷号 | 64期号:11页码:1929-1948 |
| ISSN号 | 1674-7305 |
| 关键词 | new chimeric genes essential function NAD plus rate-limiting enzyme coevolution COLONY-ENHANCING FACTOR DE-NOVO ORIGINATION PHYLOGENETIC ANALYSIS PROTEIN DIVERSITY RAPID EVOLUTION DUPLICATE GENES GENERATION TIME PATHWAY YOUNG NEOFUNCTIONALIZATION |
| DOI | 10.1007/s11427-020-1851-0 |
| 英文摘要 | The origination of new genes is important for generating genetic novelties for adaptive evolution and biological diversity. However, their potential roles in embryonic development, evolutionary processes into ancient networks, and contributions to adaptive evolution remain poorly investigated. Here, we identified a novel chimeric gene family, the chiron family, and explored its genetic basis and functional evolution underlying the adaptive evolution of Danioninae fishes. The ancestral chiron gene originated through retroposition of nampt in Danioninae 48-54 million years ago (Mya) and expanded into five duplicates (chiron1-5) in zebrafish 1-4 Mya. The chiron genes (chirons) likely originated in embryonic development and gradually extended their expression in the testis. Functional experiments showed that chirons were essential for zebrafish embryo development. By integrating into the NAD(+) synthesis pathway, chirons could directly catalyze the NAD(+) rate-limiting reaction and probably impact two energy metabolism genes (nmnat1 and naprt) to be under positive selection in Danioninae fishes. Together, these results mainly demonstrated that the origin of new chimeric chiron genes may be involved in adaptive evolution by integrating and impacting the NAD(+) biosynthetic pathway. This coevolution may contribute to the physiological adaptation of Danioninae fishes to widespread and varied biomes in Southeast Asian. |
| WOS记录号 | WOS:000613335800005 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73647]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 4.Huazhong Agr Univ, Wuhan 430070, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang,Chengchi,Gan,Xiaoni,Zhang,Chengjun,et al. The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels[J]. SCIENCE CHINA-LIFE SCIENCES,2021,64(11):1929-1948. |
| APA | Fang,Chengchi,Gan,Xiaoni,Zhang,Chengjun,&He,Shunping.(2021).The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels.SCIENCE CHINA-LIFE SCIENCES,64(11),1929-1948. |
| MLA | Fang,Chengchi,et al."The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels".SCIENCE CHINA-LIFE SCIENCES 64.11(2021):1929-1948. |
入库方式： OAI收割
来源：昆明植物研究所
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