Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells
文献类型：期刊论文
| 作者 | Dong,Fa-Wu; Li,Fang; Ren,Jia-Jia; Zhao,Cheng-Mei; Diao,Hong-Li; Li,Bao-Jing; Li,Yan-Ping; Hu,Jiang-Miao; He,Hong-Ping |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2021 |
| 卷号 | 35期号:5页码:757-762 |
| 关键词 | Valeriana amurensis sesquiterpenoids central nervous system PC12 cells NERVE GROWTH-FACTOR IRIDOID GLYCOSIDES |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2019.1603223 |
| 英文摘要 | Two new sesquiterpenoids, including a kessane-type sesquiterpenoid (1) and one bisabolane derivative (2), together with fourteen known sesquiterpenoids (3-16), were isolated from the roots and rhizomes of Valeriana amurensis. The structures of new compounds were established on the basis of extensive spectroscopic analysis. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells. As a results, four compounds including 10-12 and 15 showed potent promoting effects at the concentration of 10 mu M on NGF-induced neurite outgrowth in PC12 cells with the differentiation rate of 11.84%, 12.21%, 13.77% and 12.16%, respectively.[GRAPHICS]. |
| WOS记录号 | WOS:000470405900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73650]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming, Yunnan, Peoples R China 2.[Dong, Fa-Wu 3.Li, Fang 4.Ren, Jia-Jia 5.Zhao, Cheng-Mei 6.Diao, Hong-Li 7.Li, Bao-Jing 8.Li, Yan-Ping 9.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong,Fa-Wu,Li,Fang,Ren,Jia-Jia,et al. Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells[J]. NATURAL PRODUCT RESEARCH,2021,35(5):757-762. |
| APA | Dong,Fa-Wu.,Li,Fang.,Ren,Jia-Jia.,Zhao,Cheng-Mei.,Diao,Hong-Li.,...&He,Hong-Ping.(2021).Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells.NATURAL PRODUCT RESEARCH,35(5),757-762. |
| MLA | Dong,Fa-Wu,et al."Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells".NATURAL PRODUCT RESEARCH 35.5(2021):757-762. |
入库方式： OAI收割
来源：昆明植物研究所
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