Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii
文献类型：期刊论文
| 作者 | Zhang,Zi-Zhen; Zeng,Yan-Rong; Li,Ya-Nan; Hu,Zhan-Xing; Huang,Lie-Jun; Gu,Wei ; Hao,Xiao-Jiang; Yuan,Chun-Mao
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 19期号:1页码:216-219 |
| 关键词 | ASSISTED STRUCTURE ELUCIDATION DERIVATIVES |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/d0ob02072a |
| 英文摘要 | Hypsampsone A (1) and hyperhexanone F (2), two novel seco-polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum sampsonii. Hypsampsone A (1) features the first spirocyclic system fused with 5/6/5/5 tetracyclic skeleton. Hyperhexanone F (2) represents the second novel 1,2-seco-bicyclo[3.3.1]-PPAP skeleton. Their structures were established by extensive spectroscopic analysis, computer-assisted structure elucidation software, and calculated electronic circular dichroism spectra. A plausible biogenetic pathway of 1 was also proposed. Compounds 1 and 2 showed moderate multidrug resistance reversal activity to adriamycin (ADR) resistant cancer cell lines, HepG2/ADR and MCF-7/ADR, with the fold-reversals ranging from 16 to 38 at noncytotoxic concentration of 10 mu M. |
| WOS记录号 | WOS:000607351800018 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73653]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Boanty, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Zeng, Yan-Rong 3.Li, Ya-Nan 4.Hu, Zhan-Xing 5.Huang, Lie-Jun 6.Gu, Wei 7.Hao, Xiao-Jiang 8.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 9.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China 10.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang,Zi-Zhen,Zeng,Yan-Rong,Li,Ya-Nan,et al. Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021,19(1):216-219. |
| APA | Zhang,Zi-Zhen.,Zeng,Yan-Rong.,Li,Ya-Nan.,Hu,Zhan-Xing.,Huang,Lie-Jun.,...&Yuan,Chun-Mao.(2021).Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii.ORGANIC & BIOMOLECULAR CHEMISTRY,19(1),216-219. |
| MLA | Zhang,Zi-Zhen,et al."Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii".ORGANIC & BIOMOLECULAR CHEMISTRY 19.1(2021):216-219. |
入库方式： OAI收割
来源：昆明植物研究所
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