Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors
文献类型：期刊论文
| 作者 | Chen,Duo-Zhi; Fan,Shi-Rui; Yang,Bi-Juan; Yao,Huo-Chun; Wang,Yi-Ting; Cai,Jie-Yun; Jing,Chen-Xu; Pan,Zi-Hao; Luo,Miao; Yuze,Yan-Qiu |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2021 |
| 卷号 | 84期号:4页码:1175-1184 |
| ISSN号 | 0163-3864 |
| 关键词 | PROTEIN CORONAVIRUSES SARS PARTICLES INSIGHTS HSC70 |
| DOI | 10.1021/acs.jnatprod.0c01252 |
| 英文摘要 | Porcine epidemic diarrhea virus (PEDV) has become increasingly problematic around the world, not only for its hazards to livestock but also due to the possibility that it is a zoonotic disease. Although vaccine therapy has made some progress toward PEDV control, additional effective therapeutic strategies against PEDV are needed, such as the development of chemotherapeutic agents. The aim of this work was to identify novel anti-PEDV agents by designing and synthesizing a series of phenanthridine derivatives. Among them, three compounds (compounds 1, 2, and 4) were identified as potent anti-PEDV agents exhibiting suppression of host cell heat shock cognate 70 (Hsc70) expression. Mechanism studies revealed that host Hsc70 is involved in the replication of PEDV, and its expression can be suppressed by destabilization of the mRNA, resulting in inhibition of PEDV replication. Activity against PEDV in vivo in PEDV-infected piglets suggested that phenanthridine derivatives are the first host-acting potential anti-PEDV agents. |
| WOS记录号 | WOS:000644478400024 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73656]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.[Chen, Duo-Zhi 2.Fan, Shi-Rui 3.Yang, Bi-Juan 4.Wang, Yi-Ting 5.Cai, Jie-Yun 6.Jing, Chen-Xu 7.[Fan, Shi-Rui 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.[Yao, Huo-Chun |
| 推荐引用方式 GB/T 7714 | Chen,Duo-Zhi,Fan,Shi-Rui,Yang,Bi-Juan,et al. Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1175-1184. |
| APA | Chen,Duo-Zhi.,Fan,Shi-Rui.,Yang,Bi-Juan.,Yao,Huo-Chun.,Wang,Yi-Ting.,...&Hao,Xiao-Jiang.(2021).Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors.JOURNAL OF NATURAL PRODUCTS,84(4),1175-1184. |
| MLA | Chen,Duo-Zhi,et al."Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1175-1184. |
入库方式： OAI收割
来源：昆明植物研究所
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