Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai
文献类型：期刊论文
| 作者 | He,Xiao-Feng; Chen,Ji-Jun ; Li,Tian-Ze; Hu,Jing; Huang,Xiao-Yan; Zhang,Xue-Mei; Guo,Yuan-Qiang; Geng,Chang-An
|
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 39期号:11页码:3051-3063 |
| 关键词 | Alpinia katsumadai Katsumadainols B-1-B-15 Natural products Structure elucidation Biological activity TYROSINE-PHOSPHATASE 1B GLYCOGEN-PHOSPHORYLASE ALPHA-GLUCOSIDASE ABSOLUTE-CONFIGURATION STRUCTURE ELUCIDATION DUAL INHIBITION SEEDS CONSTITUENT DERIVATIVES CHALCONE |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202100469 |
| 英文摘要 | Main observation and conclusion The EtOAc fraction of Alpinia katsumadai seeds showed significant inhibition on glycogen phosphorylase a (GPa) with inhibitory ratios of 97.9% and 64.6% at concentrations of 200 and 100 mu g/mL, respectively. Bioactivity-guided isolation afforded 15 new diarylheptanoid-flavanone hybrids, katsumadainols B-1-B-15 (1-15), together with eight known ones (16-23). Compounds 4-10 and 12-21 exhibited activity against GPa with IC50 values of 10.1-95.4 mu mol/L; compounds 4, 5, 16, and 17 displayed inhibitory effects on alpha-glucosidase with IC50 values of 7.1, 12.4, 7.2, and 8.3 mu mol/L, obviously higher than acarbose (IC50, 209.1 mu mol/L); compounds 4-6, 14, 16-20, 22, and 23 were PTP1B/TCPTP selective inhibitors with IC50 values of 40.7-95.8 mu mol/L; compounds 4, 5, 16, and 17 showed DPP4 inhibitory effects with inhibitory ratios of 50.0%-54.2% (200 mu mol/L). Diarylheptanoid-flavanone hybrids (4, 5, 16, and 17) with a p-hydroxybenzyl at C-6 position represent a promising class of multiple-target antidiabetic agents inhibiting GPa, alpha-glucosidase, PTP1B, and DPP4. |
| WOS记录号 | WOS:000692937500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73675]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Zhang, Xue-Mei 2.[He, Xiao-Feng 3.Chen, Ji-Jun 4.Li, Tian-Ze 5.Hu, Jing 6.Huang, Xiao-Yan 7.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 8.Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China 9.Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China 10.Univ Chinese Acad Sci, Chinang 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | He,Xiao-Feng,Chen,Ji-Jun,Li,Tian-Ze,et al. Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai[J]. CHINESE JOURNAL OF CHEMISTRY,2021,39(11):3051-3063. |
| APA | He,Xiao-Feng.,Chen,Ji-Jun.,Li,Tian-Ze.,Hu,Jing.,Huang,Xiao-Yan.,...&Geng,Chang-An.(2021).Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai.CHINESE JOURNAL OF CHEMISTRY,39(11),3051-3063. |
| MLA | He,Xiao-Feng,et al."Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai".CHINESE JOURNAL OF CHEMISTRY 39.11(2021):3051-3063. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。