Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus
文献类型：期刊论文
| 作者 | Deng,Zhen-Tao; Li,Wen-Yan; Wang,Lei ; Zhou,Zhi-Ping; Wu,Xing-De; Ding,Zhong-Tao; Zhao,Qin-Shi
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| 刊名 | MOLECULES
 |
| 出版日期 | 2021 |
| 卷号 | 26期号:21页码:6516 |
| 关键词 | Catharanthus roseus monoterpene indole alkaloid catharanosine A Ca(v)3 1 low voltage-gated calcium channel (LVGCC) VINCA ALKALOIDS CELL-PROLIFERATION N-OXIDE SARPAGINE BIOSYNTHESIS VINORELBINE VINBLASTINE MECHANISM ROOTS BASES |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules26216516 |
| 英文摘要 | Catharanthus roseus is a well-known traditional herbal medicine for the treatment of cancer, hypertension, scald, and sore in China. Phytochemical investigation on the twigs and leaves of this species led to the isolation of two new monoterpene indole alkaloids, catharanosines A (1) and B (2), and six known analogues (3-8). Structures of 1 and 2 were established by H-1-, C-13- and 2D-NMR, and HREIMS data. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 2 represented an unprecedented aspidosperma-type alkaloid with a 2-piperidinyl moiety at C-10. Compounds 6-8 exhibited remarkable Ca(v)3.1 low voltage-gated calcium channel (LVGCC) inhibitory activity with IC50 values of 11.83 & PLUSMN; 1.02, 14.3 & PLUSMN; 1.20, and 14.54 & PLUSMN; 0.99 mu M, respectively. |
| WOS记录号 | WOS:000719074500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73717]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.[Deng, Zhen-Tao 3.Zhou, Zhi-Ping 4.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China 5.Li, Wen-Yan 6.Wang, Lei 7.Wu, Xing-De 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 9.Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China 10.Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng,Zhen-Tao,Li,Wen-Yan,Wang,Lei,et al. Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus[J]. MOLECULES,2021,26(21):6516. |
| APA | Deng,Zhen-Tao.,Li,Wen-Yan.,Wang,Lei.,Zhou,Zhi-Ping.,Wu,Xing-De.,...&Zhao,Qin-Shi.(2021).Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus.MOLECULES,26(21),6516. |
| MLA | Deng,Zhen-Tao,et al."Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus".MOLECULES 26.21(2021):6516. |
入库方式： OAI收割
来源：昆明植物研究所
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