Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy
文献类型：期刊论文
| 作者 | Yang,Bao-Jia; Wang,Juan; Zeng,Zheng-Quan; Yang,Xu; Huang,Ai-Ying; Hao,Xiao-Jiang ; Ding,Xiao; Li,Shun-Lin
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| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2021 |
| 关键词 | Carpesium abrotanoides L sesquiterpene lactone autophagy lysosomal biogenesis cytotoxic activity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2021.1955881 |
| 英文摘要 | Fourteen sesquiterpene lactones were isolated from the whole plant of Carpesium abrotanoides L. Their structures were determined on the basis of comprehensive spectroscopic data analysis. All compounds were screened for their cytotoxic activity, and compound 6 showed the strongest activity (IC50 2.73 - 7.21 mu M) against five human cancer cell lines, including A549, HepG2, HCT116, MDA-MB-231, and CNE2. Compound 6 was further investigated. Compound 6 effectively induced G2/M cell cycle arrest and ROS accumulation in a dose-dependent manner, which further led to apoptosis in cancer cells. Interestingly, compounds 1 and 6 could also activate protective autophagy, which was reported for the first time in sesquiterpene isolated from Carpesium abrotanoides. In addition, compounds 1 and 6 could induce lysosomal biogenesis by 173.2% and 163.7%, respectively. In sum, sesquiterpene lactones from Carpesium abrotanoides could induce apoptosis and protective autophagy in cancer cells, which provide a serial of compounds with potential clinical applications. |
| WOS记录号 | WOS:000675701600001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73720]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.[Wang, Juan 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Shaanxi Normal Univ, Xian, Peoples R China 4.[Yang, Bao-Jia 5.Wang, Juan 6.Zeng, Zheng-Quan 7.Yang, Xu 8.Huang, Ai-Ying 9.Hao, Xiao-Jiang 10.Ding, Xiao |
| 推荐引用方式 GB/T 7714 | Yang,Bao-Jia,Wang,Juan,Zeng,Zheng-Quan,et al. Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy[J]. NATURAL PRODUCT RESEARCH,2021. |
| APA | Yang,Bao-Jia.,Wang,Juan.,Zeng,Zheng-Quan.,Yang,Xu.,Huang,Ai-Ying.,...&Li,Shun-Lin.(2021).Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy.NATURAL PRODUCT RESEARCH. |
| MLA | Yang,Bao-Jia,et al."Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy".NATURAL PRODUCT RESEARCH (2021). |
入库方式： OAI收割
来源：昆明植物研究所
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