Phaeosphspirone (1/1 '), a pair of unique polyketide enantiomers with an unusual 6/5/5/6 tetracyclic ring from the desert plant endophytic fungus Phaeosphaeriaceae sp.
文献类型：期刊论文
| 作者 | Xu,Zhen-Lu; Yan,Dao-Jiang; Tan,Xiang-Mei; Niu,Shu-Bin; Yu,Meng; Sun,Bing-Da; Ding,Cai-Feng; Zhang,Yong-Gang; Ding,Gang |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2022 |
| 卷号 | 194页码:112969 |
| 关键词 | Phaeosphspirone Phaeosphaeriaceae Absolute configurations Biosynthetic pathway Cytotoxicity ASSISTED STRUCTURE ELUCIDATION BIOSYNTHESIS REVISION |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.112969 |
| 英文摘要 | Phaeosphspirone, an undescribed polyketide with a unique 6/5/5/6-fused tetracyclic system, and two known analogues, herbarin and O-methylherbarin, were purified from the endophytic fungus Phaeosphaeriaceae sp. isolated from the desert plant Bassia dasyphylla. The connectivity and relative configuration of phaeosphspirone was elucidated by comprehensive HR-ESI-MS and NMR analysis together with a computer-assisted structure elucidation (CASE) method. A pair of enantiomers existing in phaeosphspirone were separated by HPLC chromatography after reacting with chiral reagents, from which the absolute configuration of phaeosphspirone was simultaneously determined based on Mosher's rule. This tandem strategy provides a useful approach for the separation and stereochemical determination of enantiomers possessing secondary hydroxyl groups. The structural feature of phaeosphspirone, herbarin and O-methylherbarin together with gene cluster analysis suggested their polyketide biosynthetic origin. Herbarin and O-methylherbarin exhibited moderate cytotoxicity against three cancer cell lines. |
| WOS记录号 | WOS:000737602700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73721]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Beijing City Univ, Sch Biol Med, Beijing 450046, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.[Xu, Zhen-Lu 4.Tan, Xiang-Mei 5.Yu, Meng 6.Peking Union Med Coll & Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China 7.Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan 250103, Shandong, Peoples R China 8.Shandong Normal Univ, Coll Life Sci, Jinan 250014, Shandong, Peoples R China 9.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China 10.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu,Zhen-Lu,Yan,Dao-Jiang,Tan,Xiang-Mei,et al. Phaeosphspirone (1/1 '), a pair of unique polyketide enantiomers with an unusual 6/5/5/6 tetracyclic ring from the desert plant endophytic fungus Phaeosphaeriaceae sp.[J]. PHYTOCHEMISTRY,2022,194:112969. |
| APA | Xu,Zhen-Lu.,Yan,Dao-Jiang.,Tan,Xiang-Mei.,Niu,Shu-Bin.,Yu,Meng.,...&Ding,Gang.(2022).Phaeosphspirone (1/1 '), a pair of unique polyketide enantiomers with an unusual 6/5/5/6 tetracyclic ring from the desert plant endophytic fungus Phaeosphaeriaceae sp..PHYTOCHEMISTRY,194,112969. |
| MLA | Xu,Zhen-Lu,et al."Phaeosphspirone (1/1 '), a pair of unique polyketide enantiomers with an unusual 6/5/5/6 tetracyclic ring from the desert plant endophytic fungus Phaeosphaeriaceae sp.".PHYTOCHEMISTRY 194(2022):112969. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。