Biosynthetically Inspired Divergent Syntheses of Merocytochalasans
文献类型：期刊论文
| 作者 | Long,Xianwen; Wu,Hai; Ding,Yiming; Qu,Chunlei; Deng,Jun |
| 刊名 | CHEM
 |
| 出版日期 | 2021 |
| 卷号 | 7期号:1页码:212-223 |
| ISSN号 | 2451-9294 |
| 关键词 | RING-SYSTEM REARRANGEMENTS DIMER |
| DOI | 10.1016/j.chempr.2020.11.010 |
| 英文摘要 | Merocytochalasans (asperchalasines, epicochalasines, aspergilasines, asperflavipines, and amichalasines) are a class of fungal metabolites with intriguing structures and anti-cancer activity. They stem from unique biosynthetic pathways that lead to the incorporation of epicoccine and aspochalasin D motifs. A concise, scalable, and divergent synthetic route is needed to enable the preparation of sufficient quantities of merocytochalasan derivatives for biological studies. Here, we report a bioinspired modular syntheses of a suite of merocytochalasans by taking advantage of a biomimetic [5+2] heterocycloaddition of an ortho-quinone intermediate. This novel strategic approach has now made possible the divergent syntheses of several natural products, including epicochalasines A and B, asepergilasines A-D, asperflavipines A and B, and amichalasines A and B. Our bioinspired approach to the preparation of these merocytochalasans may, in turn, help to elucidate the biosynthetic pathway of merocytochalasans congeners and enable the future discovery of natural products not yet isolated. |
| WOS记录号 | WOS:000608487200020 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73728]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, 132 Lanhei Rd, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, 132 Lanhei Rd, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long,Xianwen,Wu,Hai,Ding,Yiming,et al. Biosynthetically Inspired Divergent Syntheses of Merocytochalasans[J]. CHEM,2021,7(1):212-223. |
| APA | Long,Xianwen,Wu,Hai,Ding,Yiming,Qu,Chunlei,&Deng,Jun.(2021).Biosynthetically Inspired Divergent Syntheses of Merocytochalasans.CHEM,7(1),212-223. |
| MLA | Long,Xianwen,et al."Biosynthetically Inspired Divergent Syntheses of Merocytochalasans".CHEM 7.1(2021):212-223. |
入库方式： OAI收割
来源：昆明植物研究所
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