Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism
文献类型：期刊论文
| 作者 | Zhu,Yan-Yan; Jin,Qiong; Chen,Shan-Shan; Jin,Dan-Ni; Wang,Zhao-Jie; He,Ying-Jie; Chen,Hui-Cheng; Zhao,Yun-Li; Zhao,Li-Xing; Dai,Zhi |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 29页码:115849 |
| 关键词 | Neothalfine Bisbenzylisoquinoline alkaloid Metastatic colorectal cancer Metabolomic Mitochondrial apoptosis SMALL MOLECULES IRINOTECAN RESISTANCE CELL IMMUNOTHERAPY OPPORTUNITIES CHEMOTHERAPY VINORELBINE ALKALOIDS PATHWAY |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2020.115849 |
| 英文摘要 | Neothalfine is a natural bisbenzylisoquinoline alkaloid with the abundant resource in medicinal plants and has not been reported its anti-tumor efficacy. In the present study, the anti-tumor efficacy was investigated and it showed broad-spectrum activity against several cancer cell lines, especially metastatic colorectal cancer (HCT116, SW620, T84) with the IC50 values of 7.2, 5.9, 8.2 nM, respectively, roughly equal to well-known antitumor agent docetaxel (4.0, 4.7, 2.7 nM) and nearly 1000 folds than CPT-11 (4.4, 5.1, 6.9 mu M). Furthermore, neothalfine inhibited colorectal cell proliferation by resulting in cell cycle arrest at the G2/M phase and induced apoptosis through the dysfunction of mitochondria to trigger intrinsic apoptotic pathway by untargeted metabolomic method, mitochondrial membrane potential, and caspase-3/7 activity assay. Moreover, neothalfine damaged colorectal cancer clonal spheres expansion significantly at the concentration of 3.5 nM with nearly 1000 folds efficacy than CPT-11 (3.0 mu M). The results supported that neothalfine might be an anti-tumor lead for further investigation. |
| WOS记录号 | WOS:000612172300009 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73730]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Jin, Dan-Ni 2.[Zhu, Yan-Yan 3.Chen, Shan-Shan 4.Wang, Zhao-Jie 5.He, Ying-Jie 6.Chen, Hui-Cheng 7.Zhao, Yun-Li 8.Zhao, Li-Xing 9.Dai, Zhi 10.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu,Yan-Yan,Jin,Qiong,Chen,Shan-Shan,et al. Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2021,29:115849. |
| APA | Zhu,Yan-Yan.,Jin,Qiong.,Chen,Shan-Shan.,Jin,Dan-Ni.,Wang,Zhao-Jie.,...&Luo,Xiao-Dong.(2021).Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism.BIOORGANIC & MEDICINAL CHEMISTRY,29,115849. |
| MLA | Zhu,Yan-Yan,et al."Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism".BIOORGANIC & MEDICINAL CHEMISTRY 29(2021):115849. |
入库方式： OAI收割
来源：昆明植物研究所
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