Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction
文献类型：期刊论文
| 作者 | Li,Tian-Ze; Yang,Xiao-Tong; Wang,Jin-Ping; Geng,Chang-An; Ma,Yun-Bao; Su,Li-Hua; Zhang,Xue-Mei; Chen,Ji-Jun
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 23期号:21页码:8380-8384 |
| 关键词 | TRIMERS |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c03120 |
| 英文摘要 | The biomimetic synthesis of guaianolide dialers lavandiolides H, I, and K and artematrolide F containing a spirolactone moiety has been accomplished for the first time from naturally abundant arglabin in four to six steps with an overall yield up to 60%, and a series of natural product-like guaianolide dimers, trimer, and tetramer were also successfully synthesized. Notably, the trimeric compound exhibited antihepatoma cytotoxicity more potent than that of sorafenib with IC50 values of 6.2 mu M (HepG2), 6.8 mu M (Huh7), and 7.2 mu M (SK-HEP-1). |
| WOS记录号 | WOS:000716793100052 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73752]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Su, Li-Hua 2.Zhang, Xue-Mei 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.[Li, Tian-Ze 7.Yang, Xiao-Tong 8.Wang, Jin-Ping 9.Geng, Chang-An 10.Ma, Yun-Bao |
| 推荐引用方式 GB/T 7714 | Li,Tian-Ze,Yang,Xiao-Tong,Wang,Jin-Ping,et al. Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction[J]. ORGANIC LETTERS,2021,23(21):8380-8384. |
| APA | Li,Tian-Ze.,Yang,Xiao-Tong.,Wang,Jin-Ping.,Geng,Chang-An.,Ma,Yun-Bao.,...&Chen,Ji-Jun.(2021).Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction.ORGANIC LETTERS,23(21),8380-8384. |
| MLA | Li,Tian-Ze,et al."Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction".ORGANIC LETTERS 23.21(2021):8380-8384. |
入库方式： OAI收割
来源：昆明植物研究所
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