Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens
文献类型：期刊论文
| 作者 | Su,Li-Hua; Ma,Yun-Bao; Geng,Chang-An; Li,Tian-Ze; Huang,Xiao-Yan; Hu,Jing; Zhang,Xin; Tang,Shuang; Shen,Cheng; Gao,Zhen |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 114页码:105072 |
| 关键词 | Artemisia atrovirens guaiane-type sesquiterpenoids artematrovirenins A-P HepG2 and Huh7 cell lines antihepatic cytotoxicity LACTONES CONSTITUENTS GUAIANOLIDES |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.105072 |
| 英文摘要 | Random screening revealed that the EtOH extract of Artemisia atrovirens showed significant cytotoxicity against two human hepatoma cell lines (HepG2 and Huh7) with the inhibitory ratio of 98.9% and 99.7% at the concentration of 100 mu g/mL. Further bioactivity-guided isolation of active fraction led to 16 new guaiane-type sesquiterpenoids, artematrovirenins A-P (1-16). Their structures were elucidated by extensive spectroscopic data. The absolute stereochemistry of compounds 1 and 14 was determined by single-crystal X-ray diffraction analyses. Pharmacological evaluation suggested that five compounds (3, 5, 8, 10, and 15) exhibited cytotoxicity, compounds 3 and 5 displayed cytotoxicity against HepG2 cell line with an IC50 values of 8.0 and 16.0 mu M, as well as against Huh7 cell line with values of 18.2 and 32.2 mu M. |
| WOS记录号 | WOS:000689510400006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73754]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Geng, Chang-An 2.Ma, Yun-Bao 3.Li, Tian-Ze 4.Huang, Xiao-Yan 5.Hu, Jing 6.[Su, Li-Hua 7.Zhang, Xin 8.Tang, Shuang 9.Shen, Cheng 10.Gao, Zhen |
| 推荐引用方式 GB/T 7714 | Su,Li-Hua,Ma,Yun-Bao,Geng,Chang-An,et al. Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens[J]. BIOORGANIC CHEMISTRY,2021,114:105072. |
| APA | Su,Li-Hua.,Ma,Yun-Bao.,Geng,Chang-An.,Li,Tian-Ze.,Huang,Xiao-Yan.,...&Chen,Ji-Jun.(2021).Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens.BIOORGANIC CHEMISTRY,114,105072. |
| MLA | Su,Li-Hua,et al."Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens".BIOORGANIC CHEMISTRY 114(2021):105072. |
入库方式： OAI收割
来源：昆明植物研究所
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