Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2
文献类型：期刊论文
| 作者 | Wang,Yajun; Chang,Wenhui; Li,Xuezheng; Jiang,Zhe; Zhou,Di; Feng,Yuan; Li,Bingxin; Chen,Gang; Li,Ning |
| 刊名 | JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2022 |
| 卷号 | 76期号:1页码:119-131 |
| 关键词 | APG Lung injury Nm SiO2 Nrf2 Chemoprevention OCCUPATIONAL SILICA EXPOSURE OXIDATIVE STRESS PARTICULATE MATTER INDUCED APOPTOSIS CELL-LINE CANCER PROTECTS NEUROPROTECTION INFLAMMATION TOXICITY |
| ISSN号 | 1340-3443 |
| DOI | 10.1007/s11418-021-01561-7 |
| 英文摘要 | Apigenin (APG) is a flavonoid widely distributed in fruits, vegetables, and herbs, with comprehensive pharmacological effects. In this paper, we report that APG can elicit a protective effect, which is comparable to those induced by gymnoside II/n-BuOH extracts of Bletilla striata, on SiO2-induced lung injury in vitro and in vivo. In vitro experiments showed that APG (25 mu M) could restore the SiO2-decreased A549 cell viability and lower the apoptotic rate and the production of intracellular reactive oxygen species (ROS) in A549 cells treated with nm SiO2. Western blot results showed that APG (25 mu M) could increase the level of Nuclear factor E2-related factor 2 (Nrf2) and its downstream proteins. In vivo experiments showed that APG (20 mg/kg) could potently alleviate the SiO2-elicited lung injury by enhancing the Nrf2 expression and thereby suppressing Bax/Bcl-2 pathway. The present study suggests that APG can significantly alleviate the SiO2-induced lung injury both in vitro and in vivo through, at least partially, activating Nrf2 expression.[GRAPHICS]. |
| WOS记录号 | WOS:000692437700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73759]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Yanbian Univ Hosp, Dept PIVAS, Yanji, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Beijing, Peoples R China 4.Guangxi Normal Univ, Sate Key Lab Chem & Mol Engn Med Resources, Guilin, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang,Yajun,Chang,Wenhui,Li,Xuezheng,et al. Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2[J]. JOURNAL OF NATURAL MEDICINES,2022,76(1):119-131. |
| APA | Wang,Yajun.,Chang,Wenhui.,Li,Xuezheng.,Jiang,Zhe.,Zhou,Di.,...&Li,Ning.(2022).Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2.JOURNAL OF NATURAL MEDICINES,76(1),119-131. |
| MLA | Wang,Yajun,et al."Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2".JOURNAL OF NATURAL MEDICINES 76.1(2022):119-131. |
入库方式： OAI收割
来源：昆明植物研究所
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