Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis
文献类型：期刊论文
| 作者 | Liu,Bo; Li,Bingxin; Zhou,Di; Wen,Xiaoyan; Wang,Yajun; Chen,Gang; Li,Ning |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 115页码:105237 |
| 关键词 | Asparagus cochinchinensis Steroidal NCI-H460 cell line Cytotoxic Apoptosis GLYCOSIDES CELL CANCER |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.105237 |
| 英文摘要 | In the ongoing research on potent antitumor agents from the rhizomes of Asparagus cochinchinensis, seven undescribed steroidal saponins asparagusoside A-G (1-7), along with twenty known ones (8-27), were isolated and elucidated via analyzing their 1D, 2D NMR, mass spectroscopic data and chemical methods. All isolated compounds were evaluated for their cytotoxic effects against human large cell lung carcinoma cells (NCI-H460) in vitro. Among them, compounds 7, 9 and 27 showed more significant antitumor activities than the positive control cisplatin (11.56 mu M) with IC50 values of 1.39, 3.04, and 2.25 mu M, respectively. Further research about asparagusoside G (7) showed G(0)/G(1) arrest in NCI-H460 cell line cycle and induced cell death by apoptosis in a dose-dependent way. |
| WOS记录号 | WOS:000704036500012 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73760]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources We, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu,Bo,Li,Bingxin,Zhou,Di,et al. Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis[J]. BIOORGANIC CHEMISTRY,2021,115:105237. |
| APA | Liu,Bo.,Li,Bingxin.,Zhou,Di.,Wen,Xiaoyan.,Wang,Yajun.,...&Li,Ning.(2021).Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis.BIOORGANIC CHEMISTRY,115,105237. |
| MLA | Liu,Bo,et al."Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis".BIOORGANIC CHEMISTRY 115(2021):105237. |
入库方式： OAI收割
来源：昆明植物研究所
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