Five undescribed steroids from Talaromyces stipitatus and their cytotoxic activities against hepatoma cell lines
文献类型：期刊论文
| 作者 | Zhang,Mi; Deng,Yanfang; Liu,Fei ; Zheng,Meijia; Liang,Yu; Sun,Weiguang; Li,Qin; Li,Xiao-Nian; Qi,Changxing; Liu,Junjun
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 189页码:112816 |
| ISSN号 | 0031-9422 |
| 关键词 | Talaromyces stipitatus Trichocomaceae Steroids Cytotoxicity ERGOSTEROL BIOSYNTHESIS METABOLITES YEAST |
| DOI | 10.1016/j.phytochem.2021.112816 |
| 英文摘要 | Five undescribed sterol derivatives, (22E,24R)-7 alpha-methoxy-5 alpha,6 alpha-epoxyergosta-8(14),22-diene-3 beta,15 beta-diol, (22E,24R)-5 alpha,6 alpha-epoxyergosta-8(14),22-diene-3 beta,7 beta,15 alpha-triol, (22E,24R)-3 beta,5 alpha-dihydroxy-14 beta,15 beta-epoxyergosta-7,22-diene-6-one, (22E,24R)-6 alpha-methoxy-7 alpha,15 beta-dihydroxyergosta-4,8(14),22-triene-3-one, and (25S)ergosta-7,24(28)-diene-3 beta,4 alpha,6 alpha,26-tetraol were isolated from the extract of Talaromyces stipitatus, along with eight known congeners. This is the first example of a class of ergosterols isolated from T. stipitatus. Their structures with absolute configurations were elucidated based on NMR spectroscopic data, ECD calculations, and X-ray crystallographic analyses. All these compounds were tested for their effects on three hepatoma cell lines including Hep3B, HepG2, and Huh-7. Moreover, (22E,24R)-5 alpha,6 alpha-epoxyergosta-8(14),22-diene-3 beta,7 beta,15 alpha-triol and (22E,24R)-9 alpha,15 alpha-dihydroxyergosta-4,6,8(14),22-tetraen-3-one were further evaluated for their impacts on cell cycle progression and apoptosis due to their pronounced cytotoxicity, to uncover their underlying mechanisms. Our results suggested that their antiproliferative activities were mainly mediated by inducing cell apoptosis. |
| WOS记录号 | WOS:000679123100004 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73766]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang,Mi,Deng,Yanfang,Liu,Fei,et al. Five undescribed steroids from Talaromyces stipitatus and their cytotoxic activities against hepatoma cell lines[J]. PHYTOCHEMISTRY,2021,189:112816. |
| APA | Zhang,Mi.,Deng,Yanfang.,Liu,Fei.,Zheng,Meijia.,Liang,Yu.,...&Zhang,Yonghui.(2021).Five undescribed steroids from Talaromyces stipitatus and their cytotoxic activities against hepatoma cell lines.PHYTOCHEMISTRY,189,112816. |
| MLA | Zhang,Mi,et al."Five undescribed steroids from Talaromyces stipitatus and their cytotoxic activities against hepatoma cell lines".PHYTOCHEMISTRY 189(2021):112816. |
入库方式： OAI收割
来源：昆明植物研究所
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