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Identification of Long Noncoding RNAs Associated With the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated With Hashimoto's Thyroiditis

文献类型：期刊论文

作者Zhang, Yu3; Lu, Kai-Ning3; Ding, Jin-Wang2; Peng, You3; Pan, Gang3; Teng, Li-Song1; Luo, Ding-Cun3
刊名FRONTIERS IN ONCOLOGY
出版日期2022-03-11
卷号12
ISSN号2234-943X
关键词Hashimoto's thyroiditis papillary thyroid carcinoma clinicopathological features long noncoding RNA microarray
DOI10.3389/fonc.2022.766016
通讯作者Teng, Li-Song(lsteng@zju.edu.cn) ; Luo, Ding-Cun(ldc65@163.com)
英文摘要Long noncoding RNAs (lncRNAs) play a significant role in cancer biology. This study aimed to determine the roles of lncRNAs in establishing the differences in clinical features between patients with papillary thyroid carcinoma (PTC) without Hashimoto's thyroiditis (HT) and patients with PTC and HT. In the present study, we detected the differentially expressed lncRNAs between tumor tissues of patients with PTC with or without HT through lncRNA microarrays. The data were verified and analyzed through qRT-PCR, cell viability, cell cycle and bioinformatics analyses. We found that 1031 lncRNAs and 1338 mRNAs were abnormally expressed in 5 tissue samples of PTC complicated with HT [PTC/HT (+)] compared with 5 samples of PTC without HT [PTC/HT (-)]. Gene Ontology and pathway analyses of the mRNAs suggested that several biological processes and pathways, particularly immune system processes, were induced in the PTC/HT (+) tissues. Twenty lncRNAs were verified in 31 PTC/HT (+) and 64 PTC/HT (-) specimens by qRT-PCR, and the results were consistent with the microarray data. Specifically, ENST00000452578, a downregulated lncRNA in PTC/HT(+), was negatively correlated with the tumor size. Cell viability assays revealed that ENST00000452578 could inhibit cell proliferation. Our results indicate that lncRNAs and mRNAs play an important role in establishing the different clinical characteristics between patients with PTC/HT(+) and patients with PTC/HT(-), and might provide new insights from the perspective of RNA for obtaining a further understanding of the clinical features related to PTC with HT.
WOS关键词CHRONIC LYMPHOCYTIC THYROIDITIS ; CANCER STATISTICS
资助项目Key Project of Medical Scientific and Technology Program in Hangzhou[2013Z04] ; Project of Medical Scientific and Technology Program in Hangzhou[A20200432] ; Medical and Health Research Program of Zhejiang Province[2019RC240] ; Key Project of Scientific and Technology of Hangzhou Health Commission[OO20190490]
WOS研究方向Oncology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000778433700001
资助机构Key Project of Medical Scientific and Technology Program in Hangzhou ; Project of Medical Scientific and Technology Program in Hangzhou ; Medical and Health Research Program of Zhejiang Province ; Key Project of Scientific and Technology of Hangzhou Health Commission
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128489]  
专题中国科学院合肥物质科学研究院
通讯作者Teng, Li-Song; Luo, Ding-Cun
作者单位1.Zhejiang Univ, Affiliated Hosp 1, Canc Ctr, Sch Med, Hangzhou, Peoples R China
2.Univ Chinese Acad Sci, Dept Head & Neck Surg, Canc Hosp, Hangzhou, Peoples R China
3.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Oncol Surg, Sch Med, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yu,Lu, Kai-Ning,Ding, Jin-Wang,et al. Identification of Long Noncoding RNAs Associated With the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated With Hashimoto's Thyroiditis[J]. FRONTIERS IN ONCOLOGY,2022,12.
APA Zhang, Yu.,Lu, Kai-Ning.,Ding, Jin-Wang.,Peng, You.,Pan, Gang.,...&Luo, Ding-Cun.(2022).Identification of Long Noncoding RNAs Associated With the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated With Hashimoto's Thyroiditis.FRONTIERS IN ONCOLOGY,12.
MLA Zhang, Yu,et al."Identification of Long Noncoding RNAs Associated With the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated With Hashimoto's Thyroiditis".FRONTIERS IN ONCOLOGY 12(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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