A Novel Prognostic Factor TIPE2 in Bladder Cancer
文献类型：期刊论文
| 作者 | Jiang, Yu4 ; Zhang, Zhiqiang4; Wang, Xian3; Feng, Zhenzhong3; Hong, Bo2; Yu, Dexin4; Wang, Yi1,4
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| 刊名 | PATHOLOGY & ONCOLOGY RESEARCH
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| 出版日期 | 2022-03-21 |
| 卷号 | 28 |
| 关键词 | epithelial-mesenchymal transition bladder cancer TIPE2 cystectomy urothelial carcinoma |
| ISSN号 | 1219-4956 |
| DOI | 10.3389/pore.2022.1610282 |
| 通讯作者 | Wang, Yi(wangyi2035@ahmu.edu.cn) |
| 英文摘要 | Objective: We sought to identify tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2/TNFAIP8L2) expression in bladder cancer and its relationship to clinicopathological findings and prognosis.Methods: Immunohistochemical (IHC) staining for TIPE2 was performed on 110 archived radical cystectomy specimens. Ten high-power fields were randomly selected from each specimen to observe and record the percentage of immunoreactive cells of TIPE2 in tumor cells (grade 0-4) and the corresponding immunostaining intensity (grade 0-3). The expression score of TIPE2 was obtained by multiplying the results of the above two scores, which ranged from 0 to 12 points. The cut-off point of the sum of the scores were defined as follows: 0-3 scores were defined as negative expression (-); >3 scores were classified as positive expression, < 7, low expression, >= 7, high expression.Results: In 110 cases, TIPE2 was stained in various degrees in bladder cancer tissues, and expressed in both nucleus and cytoplasm. 4.5% (5/110) showed negative expression, 40.9% (45/110) showed low expression, and 54.5% (60/110) showed high expression. TIPE2 expression was negatively correlated with lymph node metastasis (p = 0.004) and disease progression (p = 0.021). Survival curves were plotted to show that patients with high TIPE2 expression had a progression-free survival curve above those with negative/low TIPE2 expression (p = 0.027). In multivariate Cox proportional hazard regression analysis, TIPE2 was a protective factor for progression-free survival in bladder urothelial carcinoma (p = 0.031), pT stage (p = 0.016) was a risk factor for progression-free survival, and age was a risk factor for overall survival (p = 0.020).Conclusion: TIPE2 may be a new biomarker to predict the disease progression and prognosis of patients with urothelial carcinoma of the bladder. |
| WOS关键词 | INVASION ; STATISTICS ; CARCINOMA ; MIGRATION ; CATENIN ; CELLS ; EMT |
| 资助项目 | Open Fund Project of Anhui Provincial Key Laboratory of Medical Physics and Technology[LMPT201903] ; Scientific Research Fund Project of Anhui Academy of Translational Medicine[2021zhyx-C66] |
| WOS研究方向 | Oncology ; Pathology |
| 语种 | 英语 |
| WOS记录号 | WOS:000779327900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Open Fund Project of Anhui Provincial Key Laboratory of Medical Physics and Technology ; Scientific Research Fund Project of Anhui Academy of Translational Medicine |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128519]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Yi |
| 作者单位 | 1.Anhui Prov Inst Translat Med, Hefei, Peoples R China 2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Peoples R China 3.Anhui Med Univ, Dept Pathol, Affiliated Hosp 2, Hefei, Peoples R China 4.Anhui Med Univ, Dept Urol, Affiliated Hosp 2, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Yu,Zhang, Zhiqiang,Wang, Xian,et al. A Novel Prognostic Factor TIPE2 in Bladder Cancer[J]. PATHOLOGY & ONCOLOGY RESEARCH,2022,28. |
| APA | Jiang, Yu.,Zhang, Zhiqiang.,Wang, Xian.,Feng, Zhenzhong.,Hong, Bo.,...&Wang, Yi.(2022).A Novel Prognostic Factor TIPE2 in Bladder Cancer.PATHOLOGY & ONCOLOGY RESEARCH,28. |
| MLA | Jiang, Yu,et al."A Novel Prognostic Factor TIPE2 in Bladder Cancer".PATHOLOGY & ONCOLOGY RESEARCH 28(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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