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Characterization of microbiome and metabolite analyses in patients with metabolic associated fatty liver disease and type II diabetes mellitus

文献类型：期刊论文

作者Yang, Qiuping6; Zhang, Leisheng3,4,5; Li, Qian2; Gu, Man6; Qu, Qiu6; Yang, Xinglong6; Yi, Qinghua1; Gu, Kunli6; Kuang, Linli6; Hao, Mei6
刊名BMC MICROBIOLOGY
出版日期2022-04-15
卷号22
ISSN号1471-2180
关键词Metabolic associated fatty liver disease (MAFLD) Type II diabetes mellitus (T2DM) Gut microbiota Metabolome Clinical diagnosis
DOI10.1186/s12866-022-02526-w
通讯作者Zhang, Leisheng(leisheng_zhang@163.com) ; Yang, Hongju(hongjuyang105@163.com)
英文摘要Background State-of-the-art renewal has indicated the improvement of diagnostics of patients with metabolic associated fatty liver disease (MAFLD) and/or type II diabetes mellitus (T2DM) by dissecting the clinical characteristics as well as genomic analysis. However, the deficiency of the characterization of microbial and metabolite signatures largely impedes the symptomatic treatment. Methods For the purpose, we retrospectively analyzed the clinical data of 20 patients with MAFLD (short for "M"), 20 cases with MAFLD and T2DM (short for "MD"), together with 19 healthy donors (short for "Ctr"). Microbial and metabolite analyses were further conducted to explore the similarities and differences among the aforementioned populations based on feces and blood samples, respectively. Results Compared with those in the Ctr group, patients with M or MD revealed multifaceted similarities (e.g., Age, ALP, LDL, BUN) and distinctions in clinical indicators of liver (e.g., BMI, ALT, PCHE, CAP). With the aid of microbial and metabolite analyses as well as bioinformatic analyses, we found that the characteristics of gut microbiota (e.g., abundance, hierarchical clustering, cladogram, species) and lipid metabolism (e.g., metabolite, correlation coefficient and scatter plot) were distinct among the indicated groups. Conclusions The patients with MD revealed multifaceted similarities and distinctions in characteristics of microbiome and metabolites with those in the M and HD groups, and in particular, the significantly expressed microbes (e.g., Elusimicrobiota, Berkelbacteria, Cyanobacteria, Peregrinibacteria) and lipid metabolites (e.g., Lipid-Q-P-0765, Lipid-Q-P-0216, Lipid-Q-P-0034, Lipid-Q-P-0800), which would collectively benefit the clinical diagnosis of MAFLD and T2DM.
WOS关键词GUT MICROBIOTA ; MAFLD ; MECHANISMS
资助项目Yunnan Science and Technology Project[L-2017018] ; Yunnan Science and Technology Project[2018NS0100] ; Natural Science Foundation of Jiangxi Province[20212BAB216073] ; Science and technology projects of Guizhou Province[QKH-J-ZK[2021]-107] ; Famous Medical Specialist of High-level Talent Training Support Program in Yunnan Province ; Natural Science Foundation of Tianjin[19JCQNJC12500] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2019PT320005] ; Yunnan Geriatrics Clinical Research Center[202102AA310069] ; Jiangxi Provincial Key New Product Incubation Program - Technical Innovation Guidance Program of Shangrao[2020G002] ; Reserve Training Project of Thousand Project of Health Science and Technology Talents in Kunming[2019-sw-52] ; Department of Science and Technology of Shangrao City[2020AB002] ; Department of Science and Technology of Shangrao City[2020 K003] ; Department of Science and Technology of Shangrao City[2021F013]
WOS研究方向Microbiology
语种英语
出版者BMC
WOS记录号WOS:000782608800001
资助机构Yunnan Science and Technology Project ; Natural Science Foundation of Jiangxi Province ; Science and technology projects of Guizhou Province ; Famous Medical Specialist of High-level Talent Training Support Program in Yunnan Province ; Natural Science Foundation of Tianjin ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ; Yunnan Geriatrics Clinical Research Center ; Jiangxi Provincial Key New Product Incubation Program - Technical Innovation Guidance Program of Shangrao ; Reserve Training Project of Thousand Project of Health Science and Technology Talents in Kunming ; Department of Science and Technology of Shangrao City
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128535]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Leisheng; Yang, Hongju
作者单位1.Kunming Guandu Dist Peoples Hosp, Kunming 650220, Yunnan, Peoples R China
2.Yunnan Kunming Blood Ctr, Transfus Med Res Dept, Kunming 650011, Yunnan, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Radiat Technol & Biophys, 350 Shushanhu Rd, Hefei 230031, Peoples R China
4.Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, 204 Donggangxi Rd, Lanzhou 730000, Gansu, Peoples R China
5.Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gans, 204 Donggangxi Rd, Lanzhou 730000, Gansu, Peoples R China
6.Kunming Med Univ, Affiliated Hosp 1, Div Gastroenterol, Kunming 650031, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Qiuping,Zhang, Leisheng,Li, Qian,et al. Characterization of microbiome and metabolite analyses in patients with metabolic associated fatty liver disease and type II diabetes mellitus[J]. BMC MICROBIOLOGY,2022,22.
APA Yang, Qiuping.,Zhang, Leisheng.,Li, Qian.,Gu, Man.,Qu, Qiu.,...&Yang, Hongju.(2022).Characterization of microbiome and metabolite analyses in patients with metabolic associated fatty liver disease and type II diabetes mellitus.BMC MICROBIOLOGY,22.
MLA Yang, Qiuping,et al."Characterization of microbiome and metabolite analyses in patients with metabolic associated fatty liver disease and type II diabetes mellitus".BMC MICROBIOLOGY 22(2022).

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来源：合肥物质科学研究院

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