Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis
文献类型：期刊论文
| 作者 | Xiang, Yangfeng; Wang, Wendong; Gu, Jialei; Shang, Jinbiao |
| 刊名 | JOURNAL OF ONCOLOGY
 |
| 出版日期 | 2022-03-08 |
| 卷号 | 2022 |
| ISSN号 | 1687-8450 |
| DOI | 10.1155/2022/4818651 |
| 通讯作者 | Shang, Jinbiao(201309020227@stu.sdnu.edu.cn) |
| 英文摘要 | Circular RNAs (circRNAs) are often aberrantly expressed in human tumors and also serve a critical regulatory role in papillary thyroid cancer (PTC). The aim of this study is to investigate the expression pattern and biological role of circVANGL1 in PTC. The results revealed that circVANGL1 was significantly upregulated in human PTC samples. In addition, high circVANGL1 expression was closely associated with adverse clinical parameters of PTC patients. Our in vitro experiments further indicated that the knockdown of circVANGL1 using siRNA obviously repressed migration, proliferation, EMT, and invasion of PTC cells, while opposite effects were induced by its overexpression. We further noted that circVANGL1 could interact with miR-194 directly in PTC, and serve as a ceRNA to regulate ZEB1 function. Moreover, miR-194 inhibition markedly abrogated the effects of circVANGL1 knockdown in PTC cells. Therefore, our results provide convincing evidence that circVANGL1 may exert oncogenic effects in PTC, partly via regulating the miR-194/ZEB1 axis. |
| WOS关键词 | CELL-PROLIFERATION ; BLADDER-CANCER |
| 资助项目 | Medical Science Research Program of Zhejiang Province for Youth Talent[2019RC024] ; Applied Research Project of Commonweal Technology in Zhejiang Province[LGF20H160003] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | HINDAWI LTD |
| WOS记录号 | WOS:000779485800003 |
| 资助机构 | Medical Science Research Program of Zhejiang Province for Youth Talent ; Applied Research Project of Commonweal Technology in Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128577]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Shang, Jinbiao |
| 作者单位 | Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Head & Neck Surg,Canc Hosp,Zhejiang Canc Hos, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Yangfeng,Wang, Wendong,Gu, Jialei,et al. Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis[J]. JOURNAL OF ONCOLOGY,2022,2022. |
| APA | Xiang, Yangfeng,Wang, Wendong,Gu, Jialei,&Shang, Jinbiao.(2022).Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis.JOURNAL OF ONCOLOGY,2022. |
| MLA | Xiang, Yangfeng,et al."Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis".JOURNAL OF ONCOLOGY 2022(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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