中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis

文献类型：期刊论文

作者Zhang, Fan4,5,6; Zhou, Yanlin3,4,6; Chen, Haitao1,2; Jiang, Hao4,5,6; Zhou, Feini4,5,6; Lv, Bin3,4; Xu, Maosheng5
刊名OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
出版日期2022-03-18
卷号2022
ISSN号1942-0900
DOI10.1155/2022/6244757
通讯作者Lv, Bin(lvbin@medmail.com.cn) ; Xu, Maosheng(xums166@zcmu.edu.cn)
英文摘要The anxiety and depression caused by inflammatory bowel diseases (IBD) are known to greatly affect the mental health of patients. The mechanism of psychiatric disorders caused by IBD is not fully understood. Previous research has suggested that the gut microbiome plays a key role in IBD. Curcumin is a yellow polyphenol extracted from the rhizome of the ginger plant, which has been shown to have effects against both depression and anxiety. Research has indicated that curcumin affects the gut microbiome and exerts antianxiety and neuroprotective effects through the microbiota-gut-brain axis (MGB). However, whether curcumin can alleviate the psychiatric disorders caused by IBD and how curcumin affects the MGB axis through the gut microbiota have not been fully understood. Therefore, this study was aimed at determining the metabolic parameters and microbiological environment in the peripheral and central nervous system to determine the effects of curcumin against anxiety induced by dextran sulfate sodium salt (DSS) in mice. To elaborate on the link between the gut microbiota and how curcumin alleviates anxiety-like behaviors, we performed a fecal microbiota transplantation (FMT) experiment. The results suggested that curcumin can effectively relieve anxiety-like behaviors caused by DSS in mice. Further, curcumin treatment can alleviate disturbances in the gut microbiota and systemic disorders of lipid metabolism caused by DSS. Finally, through FMT, we verified that curcumin increased phosphatidylcholine in the prefrontal cortex of the mice and alleviated DSS-induced anxiety-like behaviors by modulating specific gut microbiota. We also revealed that Muribaculaceae may be a key part of the gut microbiota for curcumin to alleviate DSS-induced anxiety-like behaviors through the MGB axis.
WOS关键词ALZHEIMERS-DISEASE ; LIPIDS ; COLITIS ; CHOLINE ; PHOSPHATIDYLCHOLINE ; MARKERS ; STRESS
资助项目National Natural Science Foundation of China[81971600] ; National Natural Science Foundation of China[81970470] ; National Natural Science Foundation of China[81770535] ; Chinese Medicine Research Program of Zhejiang Province[2019ZA018]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000783468100002
出版者HINDAWI LTD
资助机构National Natural Science Foundation of China ; Chinese Medicine Research Program of Zhejiang Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128631]  
专题中国科学院合肥物质科学研究院
通讯作者Lv, Bin; Xu, Maosheng
作者单位1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China
2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
3.Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China
4.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Key Lab Digest Pathophysiol Zhejiang Prov, Hangzhou 310006, Zhejiang, Peoples R China
5.Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Dept Radiol, Hangzhou 310003, Zhejiang, Peoples R China
6.Zhejiang Chinese Med Univ, Sch Clin Med 1, Hangzhou 310053, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Fan,Zhou, Yanlin,Chen, Haitao,et al. Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022,2022.
APA Zhang, Fan.,Zhou, Yanlin.,Chen, Haitao.,Jiang, Hao.,Zhou, Feini.,...&Xu, Maosheng.(2022).Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022.
MLA Zhang, Fan,et al."Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。