Case Report: Hepatic Sarcoid-Like Reaction Associated With Checkpoint Inhibition in a NSCLC Patient and a Literature Review
文献类型：期刊论文
| 作者 | Lin, Yuxin3; Zhu, Wei3; Wu, Bingchen3; Lan, Huiyin1,2 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-03-10 |
| 卷号 | 12 |
| 关键词 | Sarcoid-like reaction immune checkpoint inhibitor Toripalimab PD-1 case report |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2022.824308 |
| 通讯作者 | Wu, Bingchen(wubc0572@163.com) ; Lan, Huiyin(wubc0572@163.com) |
| 英文摘要 | Immune checkpoint inhibitor (ICI) treatment has dramatically revolutionized the landscape of therapeutic approaches in multiple cancers, particularly, non-small-cell lung cancer (NSCLC). With the increasing use of programmed death-1 (PD-1) inhibitors in the clinic, the emerging toxicity profile presents a novel learning curve for clinicians. Here we report the first case of an NSCLC patient displaying sarcoid/granulomatous-like reaction (SLR, also known as GLR) in the liver during an anti-PD-1 therapy which showed efficacious response of complete regression. Also, this is the first report describing the SLR induced by toripalimab, a novel PD-1 inhibitor. Given this kind of hepatic findings can be easily mistaken as metastasis, even resulting in premature use of second-line treatments. In particular, we briefly review the clinical features of all those cases reporting sarcoidosis and SLRs manifested on different organs during anti-PD-(L)1 therapy. We anticipate that these clinical cases would help to alert the attention of clinicians that SLRs, as a rare immune-related adverse event (irAE), is manageable and that histopathological analysis is necessary before interpreting it as disease progression. |
| WOS关键词 | CELL LUNG-CANCER ; PULMONARY SARCOIDOSIS ; METASTATIC MELANOMA ; MONOCLONAL-ANTIBODY ; PEMBROLIZUMAB ; THERAPY ; PROGRESSION ; ANTI-PD-1 ; BLOCKADE |
| 资助项目 | National Natural Science Foundation of China[82102947] ; Zhejiang Provincial Natural Science Foundation of China[LQ22H160046] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000776746600001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128671]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wu, Bingchen; Lan, Huiyin |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Thorac Radiat Oncol, Canc Hosp, Hangzhou, Peoples R China 3.Hosp Chinese Med Changxing Cty, Dept Oncol, Huzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Yuxin,Zhu, Wei,Wu, Bingchen,et al. Case Report: Hepatic Sarcoid-Like Reaction Associated With Checkpoint Inhibition in a NSCLC Patient and a Literature Review[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Lin, Yuxin,Zhu, Wei,Wu, Bingchen,&Lan, Huiyin.(2022).Case Report: Hepatic Sarcoid-Like Reaction Associated With Checkpoint Inhibition in a NSCLC Patient and a Literature Review.FRONTIERS IN ONCOLOGY,12. |
| MLA | Lin, Yuxin,et al."Case Report: Hepatic Sarcoid-Like Reaction Associated With Checkpoint Inhibition in a NSCLC Patient and a Literature Review".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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