Sarcopenia is associated with prognosis in patients with esophageal squamous cell cancer after radiotherapy or chemoradiotherapy
文献类型：期刊论文
| 作者 | Qian,Junchao1,4 ; Si,Youjiao3; Zhou,Ke1; Tian,Yu1; Guo,Qisen4; Zhao,Kaikai2; Yu,Jinming4
|
| 刊名 | BMC Gastroenterology
 |
| 出版日期 | 2022-04-30 |
| 卷号 | 22 |
| 关键词 | Esophageal squamous cell cancer Sarcopenia Body composition Chemoradiotherapy Prognosis |
| DOI | 10.1186/s12876-022-02296-9 |
| 通讯作者 | Zhao,Kaikai(abcdkaikai35@126.com) ; Yu,Jinming(sdyujinming@163.com) |
| 英文摘要 | AbstractBackgroundThis study aimed to determine the prognostic value of the sarcopenia on the progression free survival (PFS) and overall survival (OS) of esophageal squamous cell cancer (ESCC) patients who received radiotherapy (RT) or chemoradiotherapy (CRT).MethodsData on clinicopathological characteristics and nutritional parameters were analyzed and correlated with PFS and OS, retrospectively. Skeletal muscle, subcutaneous, visceral and total fat tissue cross-sectional areas were evaluated on CT images at the midpoint of the 3rd lumbar vertebrae. A total of 213 patients were enrolled in this study.ResultsSarcopenia was significantly associated with subcutaneous fat content. The univariate analysis demonstrated that OS was superior in patients with non-sarcopenia, non-alcohol, NRI?≥?100, albumin?≥?40?g/L, TATI?>?83.0, SATI?>?27.8, VATI?>?49, non-anemia, cervical and upper-thoracic ESCC, T stage 1–2, N stage 0–1 and TNM stage I–II. In the multivariate analysis, sarcopenia, albumin, N stage and TNM stage were identified as independent prognostic factors of survival. This study demonstrated that sarcopenia was related to worse PFS and OS in patients with ESCC who received RT or CRT.ConclusionsSarcopenia is considered to be a useful predictor in patients with ESCC who received RT or CRT. This study also provided a conceptual basis for further prospective research on the application of the sarcopenia for patients receiving RT or CRT for intermediate- and advanced-stage ESCC. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12876-022-02296-9 |
| 出版者 | BioMed Central |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128733]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhao,Kaikai; Yu,Jinming |
| 作者单位 | 1.Chinese Academy of Sciences; Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science 2.Shandong First Medical University and Shandong Academy of Medical Sciences; Department of Radiation Oncology, Shandong Cancer Hospital and Institute 3.Shandong First Medical University and Shandong Academy of Medical Sciences; Department of Radiology, Shandong Cancer Hospital and Institute 4.Shandong First Medical University and Shandong Academy of Medical Sciences; Department of Radiation Oncology, School of Medicine, Shandong University, Shandong Cancer Hospital and Institute |
| 推荐引用方式 GB/T 7714 | Qian,Junchao,Si,Youjiao,Zhou,Ke,et al. Sarcopenia is associated with prognosis in patients with esophageal squamous cell cancer after radiotherapy or chemoradiotherapy[J]. BMC Gastroenterology,2022,22. |
| APA | Qian,Junchao.,Si,Youjiao.,Zhou,Ke.,Tian,Yu.,Guo,Qisen.,...&Yu,Jinming.(2022).Sarcopenia is associated with prognosis in patients with esophageal squamous cell cancer after radiotherapy or chemoradiotherapy.BMC Gastroenterology,22. |
| MLA | Qian,Junchao,et al."Sarcopenia is associated with prognosis in patients with esophageal squamous cell cancer after radiotherapy or chemoradiotherapy".BMC Gastroenterology 22(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。