Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks
文献类型：期刊论文
| 作者 | Shang, Wen2,3; Dai, Zhonghua2,3; Zhang, Jianjun2,3 ; Shen, Fang2,3; Sui, Nan2,3; Liang, Jing1,2,3
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| 刊名 | DEVELOPMENTAL PSYCHOBIOLOGY
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| 出版日期 | 2022-05-01 |
| 卷号 | 64期号:4页码:12 |
| 关键词 | embryonic morphine exposure inhibitory synaptic transmission medial striatum opioid gamma-aminobutyric acid |
| ISSN号 | 0012-1630 |
| DOI | 10.1002/dev.22273 |
| 通讯作者 | Liang, Jing(liangj@psych.ac.cn) |
| 英文摘要 | Studies of humans, mammalian animals, and chicks reveal that embryonic opioid exposure (EOE) changes the response to pharmacological rewards in postnatal individuals, which may be an outcome of permanent alterations to neural systems. However, the mechanism behind this alteration remains unclear. GABA transmitter has a trophic effect on early GABAergic neuronal development, and EOE decreases GABA concentration in developing brains. Here, we determined whether the development of inhibitory transmission was affected by EOE and whether altered GABA release was the underlying mechanism. We revealed that morphine administration in the early but not the late embryonic period decreased inhibitory transmission in the striatum of chicks. Meanwhile, day-old chicks with early embryonic morphine exposure showed increased psychomotor activity after acute morphine injection compared with saline-exposed chicks. Furthermore, GABA injection in the chick embryo following morphine administration mitigated damage to GABA transmission and recovered the behavioral response to acute morphine injection in chicks. Collectively, our findings suggest that abnormal GABA release in the early embryonic period induced by opioid exposure is attributable to functional and structural developments of the GABA synapse, and that the dysfunction of striatal GABA transmission may be linked to enhanced psychomotor response during initial drug exposure in postnatal life. |
| 收录类别 | SCI |
| WOS关键词 | GABAERGIC SYNAPTIC-TRANSMISSION ; INTERMEDIATE MEDIAL MESOPALLIUM ; GABA(A) RECEPTOR ; BEHAVIORAL SENSITIZATION ; SEIZURE SUSCEPTIBILITY ; PRENATAL EXPOSURE ; NUCLEUS-ACCUMBENS ; MORPHINE EXPOSURE ; MESSENGER-RNA ; BRAIN |
| 资助项目 | Natural Science Foundation of Beijing Municipality[5202023] ; National Natural Science Foundation of China[32071028] ; CAS-VPST Silk Road Science Fund 2021[GJHZ202129] |
| WOS研究方向 | Developmental Biology ; Psychology |
| 语种 | 英语 |
| WOS记录号 | WOS:000782458800001 |
| 出版者 | WILEY |
| 资助机构 | Natural Science Foundation of Beijing Municipality ; National Natural Science Foundation of China ; CAS-VPST Silk Road Science Fund 2021 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42450]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Liang, Jing |
| 作者单位 | 1.Univ Chinese Acad Sci, Sino Danish Ctr Educ & Res, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shang, Wen,Dai, Zhonghua,Zhang, Jianjun,et al. Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks[J]. DEVELOPMENTAL PSYCHOBIOLOGY,2022,64(4):12. |
| APA | Shang, Wen,Dai, Zhonghua,Zhang, Jianjun,Shen, Fang,Sui, Nan,&Liang, Jing.(2022).Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks.DEVELOPMENTAL PSYCHOBIOLOGY,64(4),12. |
| MLA | Shang, Wen,et al."Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks".DEVELOPMENTAL PSYCHOBIOLOGY 64.4(2022):12. |
入库方式： OAI收割
来源：心理研究所
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