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Association between Changes in Total Antioxidant Levels and Clinical Symptom Improvement in Patients with Antipsychotic-Naive First-Episode Schizophrenia after 3 Months of Risperidone Monotherapy

文献类型：期刊论文

作者Wang, Keqiang6; Xiu, Meihong5; Su, Xiuru6; Wu, Fengchun2,3,4; Zhang, Xiangyang1,4
刊名ANTIOXIDANTS
出版日期2022-04-01
卷号11期号:4页码:8
关键词schizophrenia antioxidant protection therapeutic response antipsychotics
DOI10.3390/antiox11040646
通讯作者Wu, Fengchun(13580380071@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Schizophrenia (SCZ) is associated with aberrant redox regulation in the early stages of brain development. There is growing evidence that the antioxidant defense system is closely associated with the therapeutic response to antipsychotics in SCZ patients. The aim of this study was to examine the effect of risperidone monotherapy on total antioxidant status (TAS) and the relationship between symptom improvement and changes in TAS in patients with antipsychotic-naive first-episode (ANFE) SCZ. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). Two hundred and forty-six ANFE patients were treated with risperidone for 3 months. PANSS and TAS levels were assessed at baseline and at a 3-month follow-up. Relative to healthy controls, ANFE patients had higher TAS levels, which increased even further during the treatment. Moreover, baseline TAS levels were a predictor of symptom reduction after risperidone treatment. In addition, there was a significant association between increased TAS levels and the decreased cognitive factor. Our findings suggest that antioxidant protection is possibly associated with clinical improvement in ANFE patients after risperidone treatment.
收录类别SCI
WOS关键词OXIDATIVE STRESS ; BRAIN
资助项目scientific research project of traditional Chinese medicine of Guangdong[20192070] ; science and technology project of Liwan district[201804011]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Food Science & Technology
语种英语
WOS记录号WOS:000786180000001
出版者MDPI
资助机构scientific research project of traditional Chinese medicine of Guangdong ; science and technology project of Liwan district
源URL[http://ir.psych.ac.cn/handle/311026/42478]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wu, Fengchun; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100083, Peoples R China
2.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou 510370, Peoples R China
3.Guangzhou Med Univ, Dept Biomed Engn, Guangzhou 510370, Peoples R China
4.Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou 510370, Peoples R China
5.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing 100096, Peoples R China
6.Hebei Prov Vet Hosp, Baoding 071000, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Keqiang,Xiu, Meihong,Su, Xiuru,et al. Association between Changes in Total Antioxidant Levels and Clinical Symptom Improvement in Patients with Antipsychotic-Naive First-Episode Schizophrenia after 3 Months of Risperidone Monotherapy[J]. ANTIOXIDANTS,2022,11(4):8.
APA Wang, Keqiang,Xiu, Meihong,Su, Xiuru,Wu, Fengchun,&Zhang, Xiangyang.(2022).Association between Changes in Total Antioxidant Levels and Clinical Symptom Improvement in Patients with Antipsychotic-Naive First-Episode Schizophrenia after 3 Months of Risperidone Monotherapy.ANTIOXIDANTS,11(4),8.
MLA Wang, Keqiang,et al."Association between Changes in Total Antioxidant Levels and Clinical Symptom Improvement in Patients with Antipsychotic-Naive First-Episode Schizophrenia after 3 Months of Risperidone Monotherapy".ANTIOXIDANTS 11.4(2022):8.

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来源：心理研究所

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