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Transcutaneous Auricular Vagus Nerve Stimulation Modulates the Prefrontal Cortex in Chronic Insomnia Patients: fMRI Study in the First Session

文献类型：期刊论文

作者He, Jia-Kai5,6; Jia, Bao-Hui5; Wang, Yu6; Li, Shao-Yuan6; Zhao, Bin4,6; Zhou, Zeng-Guang3; Bi, Yan-Zhi2; Wu, Mo-Zheng6; Li, Liang6; Zhang, Jin-Ling6
刊名FRONTIERS IN NEUROLOGY
出版日期2022-03-24
卷号13页码:8
ISSN号1664-2295
关键词chronic insomnia transcutaneous auricular vagus nerve stimulation functional magnetic resonance imaging (fMRI) biomarkers prefrontal cortex neuromodulation
DOI10.3389/fneur.2022.827749
通讯作者Fang, Ji-Liang(fangmgh@163.com) ; Rong, Pei-Jing(drrongpj@163.com)
英文摘要ObjectivesTranscutaneous auricular vagus nerve stimulation (taVNS) has been reported to be effective for chronic insomnia (CI). However, the appropriate population for taVNS to treat insomnia is unclear. MethodsTotal twenty-four patients with CI and eighteen health controls (HC) were recruited. Rest-state functional magnetic resonance imaging (Rs-fMRI) was performed before and after 30 min' taVNS at baseline. The activated and deactivated brain regions were revealed by different voxel-based analyses, then the seed-voxel functional connectivity analysis was calculated. In the CI group, 30 min of taVNS were applied twice daily for 4 weeks. Pittsburgh Sleep Quality Index (PSQI) and Flinders Fatigue Scale (FFS) were also assessed before and after 4 weeks of treatment in the CI group. The HC group did not receive any treatment. The correlations were estimated between the clinical scales' score and the brain changes. ResultsThe scores of PSQI (p < 0.01) and FFS (p < 0.05) decreased after 4 weeks in the CI group. Compared to the HC group, the first taVNS session up-regulated left dorsolateral prefrontal cortex (dlPFC) and decreased the functional connectivity (FCs) between dlPFC and bilateral medial prefrontal cortex in the CI group. The CI groups' baseline voxel wised fMRI value in the dlPFC were negatively correlated to the PSQI and the FFS score after 4 weeks treatment. ConclusionsIt manifests that taVNS has a modulatory effect on the prefrontal cortex in patients with CI. The initial state of dlPFC may predict the efficacy for taVNS on CI.
收录类别SCI
WOS关键词COGNITIVE CONTROL NETWORK ; REGIONAL BRAIN ACTIVITY ; DEFAULT MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; DISORDER ; MANAGEMENT ; GUIDELINE
资助项目National Key Research and Development Program[2018YFC1705800] ; National Natural Science Foundation[81473780] ; National Natural Science Foundation[81774433]
WOS研究方向Neurosciences & Neurology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000780538400001
资助机构National Key Research and Development Program ; National Natural Science Foundation
源URL[http://ir.psych.ac.cn/handle/311026/42496]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Fang, Ji-Liang; Rong, Pei-Jing
作者单位1.Guanganmen Hosp, Dept Radiol, China Acad Chinese Med Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Chinese Acad Sci, Aerospace Informat Res Inst, Key Lab Quantitat Remote Sensing Informat Technol, Beijing, Peoples R China
4.Southern Med Univ, Dept Acupuncture, Guangzhou, Peoples R China
5.Guanganmen Hosp, Dept Acupuncture, China Acad Chinese Med Sci, Beijing, Peoples R China
6.China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Dept Physiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 He, Jia-Kai,Jia, Bao-Hui,Wang, Yu,et al. Transcutaneous Auricular Vagus Nerve Stimulation Modulates the Prefrontal Cortex in Chronic Insomnia Patients: fMRI Study in the First Session[J]. FRONTIERS IN NEUROLOGY,2022,13:8.
APA He, Jia-Kai.,Jia, Bao-Hui.,Wang, Yu.,Li, Shao-Yuan.,Zhao, Bin.,...&Rong, Pei-Jing.(2022).Transcutaneous Auricular Vagus Nerve Stimulation Modulates the Prefrontal Cortex in Chronic Insomnia Patients: fMRI Study in the First Session.FRONTIERS IN NEUROLOGY,13,8.
MLA He, Jia-Kai,et al."Transcutaneous Auricular Vagus Nerve Stimulation Modulates the Prefrontal Cortex in Chronic Insomnia Patients: fMRI Study in the First Session".FRONTIERS IN NEUROLOGY 13(2022):8.

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来源：心理研究所

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