Temporal dynamic patterns of the ventromedial prefrontal cortex underlie the association between rumination and depression
文献类型：期刊论文
| 作者 | Gao, Wei5,6; Biswal, Bharat4; Yang, Jiemin6; Li, Songlin3; Wang, YanQing2; Chen, Shengdong1; Yuan, JiaJin6 |
| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2022-04-23 |
| 页码 | 14 |
| 关键词 | rumination depression spatial patterns temporal dynamics VMPFC |
| ISSN号 | 1047-3211 |
| DOI | 10.1093/cercor/bhac115 |
| 通讯作者 | Yuan, JiaJin(yuanjiajin168@126.com) |
| 英文摘要 | As a major contributor to the development of depression, rumination has proven linked with aberrant default-mode network (DMN) activity. However, it remains unclear how the spontaneous spatial and temporal activity of DMN underlie the association between rumination and depression. To illustrate this issue, behavioral measures and resting-state functional magnetic resonance images were connected in 2 independent samples (N-Sample1 = 100, N-Sample2 = 95). Fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) were used to assess spatial characteristic patterns, while voxel-wise functional concordance (across time windows) (VC) and Hurst exponent (HE) were used to assess temporal dynamic patterns of brain activity. Results from both samples consistently show that temporal dynamics but not spatial patterns of DMN are associated with rumination. Specifically, rumination is positively correlated with HE and VC (but not fALFF and ReHo) values, reflecting more consistent and regular temporal dynamic patterns in DMN. Moreover, subregion analyses indicate that temporal dynamics of the ventromedial prefrontal cortex (VMPFC) reliably predict rumination scores. Furthermore, mediation analyses show that HE and VC of VMPFC mediate the association between rumination and depression. These findings shed light on neural mechanisms of individual differences in rumination and corresponding risk for depression. |
| 收录类别 | SCI |
| WOS关键词 | DEFAULT-MODE NETWORK ; POSTERIOR CINGULATE CORTEX ; RESTING-STATE FMRI ; FUNCTIONAL CONNECTIVITY ; COGNITIVE FLEXIBILITY ; REGIONAL HOMOGENEITY ; WORKING-MEMORY ; HURST EXPONENT ; SOCIAL ANXIETY ; BRAIN ACTIVITY |
| 资助项目 | National Natural Science Foundation of China[31671164] ; National Natural Science Foundation of China[31971018] ; National Natural Science Foundation of China[31871103] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000785871700001 |
| 出版者 | OXFORD UNIV PRESS INC |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42468]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Yuan, JiaJin |
| 作者单位 | 1.Qufu Normal Univ, Sch Psychol, Qufu, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Sichuan Normal Univ, Sch Educ Sci, Chengdu, Sichuan, Peoples R China 4.New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA 5.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 6.Sichuan Normal Univ, Inst Brain & Psychol Sci, 5 Jingan Rd, Chengdu, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Wei,Biswal, Bharat,Yang, Jiemin,et al. Temporal dynamic patterns of the ventromedial prefrontal cortex underlie the association between rumination and depression[J]. CEREBRAL CORTEX,2022:14. |
| APA | Gao, Wei.,Biswal, Bharat.,Yang, Jiemin.,Li, Songlin.,Wang, YanQing.,...&Yuan, JiaJin.(2022).Temporal dynamic patterns of the ventromedial prefrontal cortex underlie the association between rumination and depression.CEREBRAL CORTEX,14. |
| MLA | Gao, Wei,et al."Temporal dynamic patterns of the ventromedial prefrontal cortex underlie the association between rumination and depression".CEREBRAL CORTEX (2022):14. |
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来源：心理研究所
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